Not Yet RecruitingPhase 2

Semaglutide (Wegovy) Treatment for Trichotillomania

10 participantsStarted 2026-05

Plain-language summary

This research study is testing the effectiveness and safety of semaglutide (Wegovy) in people with trichotillomania, also known as hair-pulling disorder.

Who can participate

Age range18 Years – 75 Years

SexALL

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Inclusion criteria

✓. Men and women age 18-75;
✓. Diagnosis of current trichotillomania based on DSM-5 criteria and confirmed using the clinician-administered MIDI (13);
✓. Hair pulling daily with urges to pull as the trigger in \>50% of the episodes of pulling;
✓. Women of childbearing age are required to have a negative result on a beta-human chorionic gonadotropin pregnancy test;
✓. Women of childbearing potential utilizing a medically accepted form of contraception defined as double barrier, oral contraceptive, injectable contraceptive, implantable contraceptive devices, and abstinence

Exclusion criteria

✕. Infrequent pulling (i.e. less than daily) or automatic pulling (i.e. no urges to pull);
✕. Unstable medical illness or clinically significant abnormalities on laboratory tests, EKG, or physical examination at screen as determined by the investigator;
✕. History of seizures;
✕. Myocardial infarction within 6 months;
✕. Current pregnancy or lactation, or inadequate contraception in women of childbearing potential;
✕. A need for medication other than semaglutide with possible psychotropic effects or unfavorable interactions as determined by the investigator;
✕. Clinically significant suicidality (defined by the Columbia Suicide-Severity Rating Scale);
✕. Lifetime history of bipolar disorder type I or II, schizophrenia, or any psychotic disorder;

What they're measuring

NIMH Trichotillomania Severity Scale

Timeframe: From screening to 1 week after last dose of study drug

Trial details

NCT IDNCT07282769

SponsorUniversity of Chicago

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2027-02

Contact for this trial

Megha Neelapu

773-702-5523 megha.neelapu@bsd.uchicago.edu

View on ClinicalTrials.gov More Trichotillomania (Hair-Pulling Disorder) trials