CompletedNot Applicable

Effect of Transcutaneous Auricular Stimulation of the Vagus Nerve on Functional Connectivity in the Brain at Rest

France84 participantsStarted 2025-12-08

Plain-language summary

The goal of this clinical trial is to study the effect of Transcutaneous Auricular Vagus Nerve Stimulation (taVNS) on resting-state brain functional connectivity. The study will assess this effect using functional Near-Infrared Spectroscopy (fNIRS) in both chronic post-stroke patients and healthy subjects. The main questions it aims to answer are: Does taVNS affect resting-state functional connectivity (measured by fNIRS) in chronic post-stroke patients? Does taVNS affect resting-state functional connectivity (measured by fNIRS) in healthy subjects? Are there differences in the effect of taVNS on functional connectivity between the post-stroke group and the healthy group? Researchers will compare the effect of active taVNS (real stimulation) to a sham stimulation (control) to evaluate its specific impact on the brain's functional networks.

Who can participate

Age range18 Years

SexALL

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AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria for post-stroke participant: * age 18 or older * Right-handed participant; * Hemiparesis in the chronic phase (\>6 months post-stroke) * Participant who has agreed to sign an informed consent form; * Participant who is affiliated with social security. Inclusion Criteria for healthy participant: * age 18 or older * Right-handed participant; * Participant who has agreed to sign an informed consent form; * Participant who is affiliated with social security. Exclusion Criteria for post-stroke participant: * Allergy to neoprene (the material used to make the fNIRS cap); * Hair volume preventing the cap from being put on and/or access to the scalp; * Cognitive impairment making it impossible to participate in the study; * Phasic disorders preventing understanding of instructions and effective communication; * Pregnant or breastfeeding women; * Persons under legal protection Exclusion Criteria for post-stroke participant: * Allergy to neoprene (the material used to make the fNIRS cap); * Hair volume preventing the cap from being put on and/or access to the scalp; * Pregnant or breastfeeding women; * Persons under legal protection

What they're measuring

Resting-State Functional Connectivity

Timeframe: Day 1

Trial details

NCT IDNCT07282106

SponsorClinique Les Trois Soleils

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2026-02-05