Active — Not RecruitingEarly Phase 1

Comparing Microneedling and Injectable Platelet Rich Fibrin to Hyaluronic Acid In Papilla Reconstruction

Saudi Arabia7 participantsStarted 2025-11-24

Plain-language summary

This randomized split-mouth clinical trial aims to compare the clinical effectiveness of microneedling combined with injectable platelet-rich fibrin (i-PRF) versus hyaluronic acid (HA) gel injection in the reconstruction of Class I interdental papilla loss. The study hypothesizes that MN + i-PRF will yield greater papillary regeneration, offering a minimally invasive, biologically active alternative to traditional surgical approaches for soft-tissue esthetic rehabilitation.

Who can participate

Age range18 Years – 45 Years

SexALL

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria: * Plaque index \<1 * Gingival index \<1 * Class I papillary loss (Nordland and Tarnow classification) * Probing depth ≤4 mm at the test site * Inter-proximal bone crest distance ≤7 mm from the contact point. Exclusion Criteria: * Pregnancy * Lactation * Uncontrolled systemic diseases (e.g., diabetes) * Anticoagulant therapy * Recent radiotherapy * Orthodontic treatment * Midline diastema * High frenum attachment * Class II/III papillary loss.

What they're measuring

Papillary height

Timeframe: Baseline, 6 weeks, and 12 weeks.

Papillary width

Timeframe: 12 weeks

Trial details

NCT IDNCT07280507

SponsorKing Abdulaziz University

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2026-03

View on ClinicalTrials.gov More Papilla Reconstruction trials