Not Yet RecruitingNot Applicable

Study of Skin and Gut Microbiome in a Skin Condition Involving Skin Barrier Impairment and Allergic Symptoms: Netherton Syndrome

France30 participantsStarted 2025-12

Plain-language summary

It is proposed to conduct an exploratory study to analyze the skin, intestinal, and salivary microbiome, as well as the skin mycobiome and virome, of patients (adolescents and young adults) with Netherton syndrome, a condition characterized by an impaired skin barrier that most likely promotes the development of allergic manifestations. The study will be conducted on patients with Netherton syndrome and control subjects in order to investigate possible correlation factors between the three microbiomes and identify which ones.

Who can participate

Age range10 Years

SexALL

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria: Group A: * Children aged 10 years and older and adults with confirmed Netherton syndrome diagnosed at age 10 years or older (clinical and histological and/or molecular) * Patients and legal guardians informed about the study and not opposed to participation in the study Group B: * Children aged 10 years and older and adults with no skin barrier impairment, dermatosis, inflammatory disease, or autoimmune disease. * Subjects and legal guardians informed about the study and who do not object to participation in the study. Exclusion Criteria: * Refusal by parents/guardians, children, adolescents, or adults. * General or local antibiotic therapy within the month preceding the consultation.

What they're measuring

Study of the skin, salivary and intestinal microbiota

Timeframe: Baseline

Trial details

NCT IDNCT07280091

SponsorAssistance Publique - Hôpitaux de Paris

Sponsor typeOTHER

Study typeOBSERVATIONAL

Primary completion2027-12

Contact for this trial

Christine BODEMER, PhD

01 44 49 46 72 christine.bodemer@aphp.fr