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Central Venous Pressure Versus Inferior Vena Cava Distensibility Index in Assessing Fluid Responsiveness in Septic Shocked Patients

70 participantsStarted 2026-01

Plain-language summary

This study aims to compare ultrasound-guided inferior vena cava distensibility index(IVC\_DI) assessment with central venous pressure (CVP) monitoring for the detection of hypovolemia in septic shocked patients in the emergency department. The primary objective is to evaluate the diagnostic accuracy and clinical utility of IVC distinsisibility index compared to CVP values in both early and post- resuscitation phases. The study will prospectively enroll septic shocked patients, collect demographic and clinical data, and analyze the correlation between IVC DI and CVP measurements to determine their role in guiding fluid resuscitation and hemodynamic management

Who can participate

Age range18 Years

SexALL

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AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

1. Inclusion criteria: * Adult patients (≥18 years old) both gender. with a clinical diagnosis of septic shock according to Sepsis-3 criteria (persistent hypotension require vasopressors to maintain MAP ≥65 mmHg and serum lactate \>2 mmol/L despite adequate fluid resuscitation).(2,3). * with a central venous catheter in place for CVP monitoring. .awho require fluid resuscitation. 2. Exclusion criteria: .pregnant patients. .Patients with significant right heart failure or severe tricuspid regurgitation (5).. .Patients with increased intra-abdominal pressure or conditions affecting IVC diameter (9). .Patients with arrhythmias (e.g., atrial fibrillation) that interfere with preload assessment (6). .Patients who refuse participation. * patients with contraindications to cvp (coagulopathy,distortion in anatomy of neck,....)

What they're measuring

To compare the accuracy of Central Venous Pressure (CVP) and Inferior Vena Cava Distensibility Index (IVC-DI) in predicting fluid responsiveness in patients with septic shock.

Timeframe: All patients will have the measurements of CVP and IVC_DI on arrival within 30 min before resuscitation and after 60 min of resuscitation

Trial details

NCT IDNCT07279064

SponsorAssiut University

Sponsor typeOTHER

Study typeOBSERVATIONAL

Primary completion2027-10

Contact for this trial

Marwa Abdelmomen Helal

01008118263 marwaamomen@gmail.com

View on ClinicalTrials.gov More Central Venous Pressure and Inferior Vena Cava Distensibility Index in Assessing Fluid Responsiveness in Septic Shocked Patients trials