This proposal aims to understand the neurobiological mechanisms of fatigue in individuals with Post-Acute Sequelae of SARS-CoV-2 Infection (PASC). This knowledge will eventually provide candidate mechanisms to target with pharmacological intervention and inform rehabilitative care for those individuals suffering from symptoms of fatigue in PASC.
Age range
18 Years – 75 Years
Sex
ALL
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A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.
Comparison between PASC and HC - difference in mean Assessment Error
Timeframe: Baseline, during experimental protocol.
Comparing between PASC and HC - difference in BBB permeability
Timeframe: Baseline, during MRI acquisition.
Comparing between PASC and HC - Regions of the brain that are sensitive to Assessment error as a function of disease state
Timeframe: Baseline, during experimental protocol.
The modulatory effect of BBB permeability on the relationship between Neural Activity and Effort Assessment
Timeframe: Baseline, during experimental protocol and MRI aquisition.
Comparing between PASC and HC - Difference in momentary subjective fatigue ratings
Timeframe: Baseline and during fatiguing exertions in the experimental protocol.
Comparing between PASC and HC - Difference in Mean Acceptance Rate of Risky Effort Options between rested/baseline and fatigue choices
Timeframe: Baseline and during fatiguing exertions in the experimental protocol.
Comparing between PASC and HC - Regions of the brain encoding a difference in effort cost between rested/baseline and fatigue choices
Timeframe: Baseline and during fatiguing exertions in the experimental protocol.
The modulatory effect of BBB permeability on the relationship between Neural Activity and change effort-based decision-making
Timeframe: Baseline, fatigueing exertion, and during experimental protocol and MRI aquisition
Comparing between PASC and HC - Difference in mean assessment error as a function of time
Timeframe: Data collections at months 0, 3, 6, 12
Comparing between PASC and HC - Difference in momentary subjective fatigue ratings as a function of time
Timeframe: Data collections at months 0, 3, 6, 12
Comparing between PASC and HC - difference in BBB permeability as a function of time
Timeframe: Data collections at months 0, 3, 6, 12
Comparing between PASC and HC - Regions of the brain that are sensitive to Assessment error as a function of disease state and time
Timeframe: Data collections at months 0, 3, 6, 12