This proposal aims to understand the neurobiological mechanisms of fatigue in individuals with Post-Acute Sequelae of SARS-CoV-2 Infection (PASC). This knowledge will eventually provide candidate mechanisms to target with pharmacological intervention and inform rehabilitative care for those individuals suffering from symptoms of fatigue in PASC.
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Comparison between PASC and HC - difference in mean Assessment Error
Timeframe: Baseline, during experimental protocol.
Comparing between PASC and HC - difference in BBB permeability
Timeframe: Baseline, during MRI acquisition.
Comparing between PASC and HC - Regions of the brain that are sensitive to Assessment error as a function of disease state
Timeframe: Baseline, during experimental protocol.
The modulatory effect of BBB permeability on the relationship between Neural Activity and Effort Assessment
Timeframe: Baseline, during experimental protocol and MRI aquisition.
Comparing between PASC and HC - Difference in momentary subjective fatigue ratings
Timeframe: Baseline and during fatiguing exertions in the experimental protocol.
Comparing between PASC and HC - Difference in Mean Acceptance Rate of Risky Effort Options between rested/baseline and fatigue choices
Timeframe: Baseline and during fatiguing exertions in the experimental protocol.
Comparing between PASC and HC - Regions of the brain encoding a difference in effort cost between rested/baseline and fatigue choices
Timeframe: Baseline and during fatiguing exertions in the experimental protocol.
The modulatory effect of BBB permeability on the relationship between Neural Activity and change effort-based decision-making
Timeframe: Baseline, fatigueing exertion, and during experimental protocol and MRI aquisition
Comparing between PASC and HC - Difference in mean assessment error as a function of time
Timeframe: Data collections at months 0, 3, 6, 12
Comparing between PASC and HC - Difference in momentary subjective fatigue ratings as a function of time
Timeframe: Data collections at months 0, 3, 6, 12
Comparing between PASC and HC - difference in BBB permeability as a function of time
Timeframe: Data collections at months 0, 3, 6, 12
Comparing between PASC and HC - Regions of the brain that are sensitive to Assessment error as a function of disease state and time
Timeframe: Data collections at months 0, 3, 6, 12