Assessment of Early Post-operative Nuclear Imaging in Neurosurgery: a Safety and Feasibility Stud… (NCT07274397) | Clinical Trial Compass
RecruitingNot Applicable
Assessment of Early Post-operative Nuclear Imaging in Neurosurgery: a Safety and Feasibility Study in Patients Operated for Glioblastoma
France15 participantsStarted 2026-04-17
Plain-language summary
This clinical trial aims to evaluate the feasibility and safety of early post-operative brain PET-MRI imaging in adult patients who have undergone surgery for suspected glioblastoma. The study also seeks to validate specific nuclear imaging parameters for better detection of residual tumor tissue compared to standard gadolinium-enhanced MRI. The main objectives are to determine whether early PET-MRI within 48 hours post-surgery is feasible, to assess potential side effects related to imaging procedures, and to explore if PET parameters such as SUVmax, metabolic volume, and tumor-to-striatum ratio can improve the detection of tumor residue. A total of 15 patients will be included at a single site in France. Participants will undergo PET-MRI using 18F-DOPA and gadolinium, and will be monitored for radiation exposure and possible adverse events up to 24 hours after imaging.
Who can participate
Age range
18 Years
Sex
ALL
See this in plain English?
AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
Inclusion Criteria:
* First resection for a suspected glioblastoma in the past 72h
* Signed informed consent
non-inclusion Criteria:
* Deprived of liberty or under legal protection (e.g, guardianship, trusteeship)
* Patients under 18 years old
* Absence of social security cover
* Pregnancy
* Emergency procedure
* Contraindication to brain MRI, including claustrophobia
* Contraindication to radiotracers or gadolinium injection
* Preoperative cognitive impairment impeding patient information
Exclusion criteria :
* Any postoperative behavioral disorders or medical condition or symptom impeding the completion of brain imaging
* Postoperative medical dependency impeding the patient transfer to the nuclear medicine department (including, but not limited to, invasive ventilation, need for external ventricular drainage…)
* Postoperative histological diagnosis different from glioblastoma
Questions worth asking your doctor
Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.
1Based on my diagnosis and history, is this trial worth exploring for me — or is there a standard treatment we should try first?
2What does this trial's phase tell us about how much is already known about its safety and benefit?
3What would taking part actually involve for me — visits, tests, time, and travel?
4What are the known and possible risks or side effects I should weigh, and how would they be monitored?
5If this trial isn't the right fit, what other options or trials would you suggest I look into?
Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.
Questions for the trial coordinator
The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.
1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?
A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.
What they're measuring
1
Assess the feasibility of performing early post-operative brain PET-MRI in neurosurgery patients
Timeframe: Within 24 hours after surgery
2
Assess the safety of performing early post-operative brain PET-MRI in neurosurgery patients
Timeframe: Within 24 hours after surgery
3
Assess the safety of performing early post-operative brain PET-MRI in neurosurgery patients
Timeframe: Whithin 24 hours after surgery
4
Assess the safety of performing early post-operative brain PET-MRI in neurosurgery patients
Timeframe: Whithin 24 hours afin surgery
5
Assess the safety of performing early post-operative brain PET-MRI in neurosurgery patients