Not Yet RecruitingPhase 3

Efficacy and Safety of Cryotherapy Followed by Tirbanibulin Ointment for Actinic Keratosis on the Scalp and Forehead

59 participantsStarted 2025-11-30

Plain-language summary

The aim of the study is to evaluate the efficacy and safety of a combined approach of cryotherapy and tirbanibulin for the treatment of actinic keratosis of the scalp and forehead, repeated every 4 months. A higher rate of complete response is expected with this combination compared to cryotherapy alone, as well as a better response with repeated treatment cycles.

Who can participate

Age range18 Years

SexALL

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Exclusion criteria

✕. Located somewhere other than the scalp and/or forehead,
✕. Within 5 cm of a wound that is not fully healed or a lesion suspicious for carcinoma,
✕. Therapeutic or cosmetic procedures (e.g., liquid nitrogen application, surgical excision, dermabrasion, medium or deep chemical peeling, laser resurfacing) in the treatment area or within 2 cm around the selected treatment area,
✕. Therapeutic products containing acids (e.g., salicylic acid, fruit acids), topical retinoids, or light peels in the treatment area or within 2 cm around the selected treatment area,

What they're measuring

Complete clearance of actinic keratosis

Timeframe: 8 months

Trial details

NCT IDNCT07273656

SponsorUniversity Hospital, Lille

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2027-11-30

View on ClinicalTrials.gov More Keratosis trials