This study evaluated the efficacy of two structured psychological interventions for patients with relapsing-remitting multiple sclerosis (RRMS). The main goal was to determine whether a Cognitive Behavioral Therapy (CBT)-based program and a Psychophysiological Regulation Therapy (PRT) improved emotional well-being and cognitive functioning compared with Standard Care (SC). A total of 140 participants with mild to moderate disability and disease duration between 5.5 and 8.5 years were randomly assigned to one of three groups: CBT, PRT, or SC (waiting list). Each intervention was delivered in small groups over 12 weekly sessions. Assessments were conducted before and after treatment using validated clinical and neuropsychological measures. Results were analyzed to explore the effectiveness of both interventions in reducing anxiety and depressive symptoms and enhancing cognitive performance. The study aimed to provide evidence for the inclusion of psychological therapies as complementary treatments in comprehensive care for multiple sclerosis patients.
Age range
18 Years – 65 Years
Sex
ALL
See this in plain English?
AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.
Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.
The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.
A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.
Fatigue Severity Scale (FSS) - Total Score
Timeframe: Baseline and 12 weeks.
Multiple Sclerosis Quality of Life-54 (MSQoL-54) - Total and Subscale Scores
Timeframe: Baseline and 12 weeks.
Multiple Sclerosis Neuropsychological Questionnaire (MSNQ) - Total Score
Timeframe: Baseline and 12 weeks.
Verbal Selective Reminding Test (SRT) - Total Recall Score
Timeframe: Baseline and 12 weeks.
10/36 Spatial Recall Test (SPART) - Total Recall Score
Timeframe: Baseline and 12 weeks.
Paced Auditory Serial Addition Test (PASAT) - 3-Second Version
Timeframe: Baseline and 12 weeks.
Symbol Digit Modalities Test (SDMT) - Oral Version
Timeframe: Baseline and 12 weeks.
Controlled Oral Word Association Test (COWAT) - Semantic Fluency ("Animals" Category)
Timeframe: Baseline and 12 weeks.
Controlled Oral Word Association Test (COWAT) - Phonemic Fluency (F-A-S Letters)
Timeframe: Baseline and 12 weeks.
Hospital Anxiety and Depression Scale - Anxiety Subscale (HADS-A)
Timeframe: Baseline and 12 weeks.
Beck Depression Inventory-II (BDI-II) - Total Score
Timeframe: Baseline and 12 weeks.
Inventario de Situaciones y Respuestas de Ansiedad (ISRA) - Total Score
Timeframe: Baseline and 12 weeks.