Impact of Semaglutide (Ozempic/Wegovy®) on Heart and Muscle Mass (NCT07272837) | Clinical Trial Compass
RecruitingNot Applicable
Impact of Semaglutide (Ozempic/Wegovy®) on Heart and Muscle Mass
Canada50 participantsStarted 2026-04-14
Plain-language summary
The aim of this study is to use advanced MRI scans to track changes in both muscle and fat in the body and heart over a 12-month period in individuals starting semaglutide. By doing so, we hope to gain a clearer understanding of how semaglutide affects muscle health and function. Our goal is to ensure the medication supports long-term well-being, particularly for people who may be at higher risk of muscle loss.
This study involves (3) in-person study visits. At each visit, participants will be asked to:
* Undergo magnetic resonance imaging (MRI) while resting and during exercise to take pictures of their heart, abdomen, and legs.
* Complete tests to assess balance, sit-to-stand, walking speed, and handgrip strength.
* Complete questionnaires related to demographics, health information, physical activity, and nutrition.
* Have a blood sample collected from a vein in your arm.
* Have your blood levels assessed through three finger pricks.
* Complete three days of food records.
Who can participate
Age range
18 Years – 80 Years
Sex
ALL
See this in plain English?
AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
Inclusion Criteria:
* Adults 18-80 years of age
* Starting semaglutide for type 2 diabetes or weight loss
* Able to safely undergo an MRI scan (including meeting the physical requirements for MRI equipment)
Exclusion Criteria:
* Current use of semaglutide for more than 2 weeks
* Major recent heart issues or other severe health conditions
* Concerns related to MRI use (including magnetic implants, pacemaker, severe claustrophobia)
* Dependence on a mobility aid (unable to participate in exercise MRI)
Questions worth asking your doctor
Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.
1Based on my diagnosis and history, is this trial worth exploring for me — or is there a standard treatment we should try first?
2What does this trial's phase tell us about how much is already known about its safety and benefit?
3What would taking part actually involve for me — visits, tests, time, and travel?
4What are the known and possible risks or side effects I should weigh, and how would they be monitored?
5If this trial isn't the right fit, what other options or trials would you suggest I look into?
Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.
Questions for the trial coordinator
The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.
1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?
A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.