The Effect of Denosumab on Muscle and Strength and Insulin Sensitivity

Inclusion Criteria: * Postmenopausal women (postmenopausal for at least two years) * Age ≥ 40 years * BMD T-score ≥ -2.0 (lumbar spine, total hip or femoral neck) * At least 2 lumbar vertebrae that can be evaluated by dual-energy x-ray absorptiometry (DXA) * Diabetes Mellitus type 2 * Treatment with metformin as monotherapy Exclusion Criteria: * Treatment for osteoporosis at any time * Other antidiabetic medication than metformin * Low-energy vertebral fractures at any time * Low-energy hip fracture at any time * Ongoing treatment with systemic glucocorticoids * Metabolic bone disease (for example osteogenesis imperfecta, Paget's disease of bone, hyperparathyroidism) * Treatment affecting bone, calcium metabolism or muscle * Active cancer within the last 5 years with the exception of basal cell skin cancer * Estimated glomerular filtration rate (eGFR) ≤ 35 mL/min * Unable to read and understand Danish * Immobility