Alii Supplement Study (NCT07271316) | Clinical Trial Compass
RecruitingPhase 2
Alii Supplement Study
United States68 participantsStarted 2026-01-12
Plain-language summary
The goal of this clinical trial is to learn if the Alii Supplement can be used to reduce symptoms related to nutritional depletion in hormonal birth control pill users. The main questions it aims to answer are:
Does usage of the supplement increase happiness, decrease perceived vulnerability to disease, increase digestive health, decrease mood swings, and increase energy?
The investigators will compare the Alii Supplement to a placebo (a capsule that contains no drug) to see if the Alii Supplement works to reduce symptoms associated with nutritional depletion.
Participants will:
Take the placebo or Alii Supplement everyday for 28 days and visit the research office twice to fill out an online survey comprising of items examining the main outcome measures.
Who can participate
Age range
18 Years – 25 Years
Sex
FEMALE
See this in plain English?
AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
Inclusion Criteria:
* Participants must be on the hormonal birth control pill as the investigators are testing the effectiveness of a supplement for women who take the hormonal birth control pill
* Participants must be willing to complete a follow up survey as this study will be multiple parts
* Participants must be willing to take a daily supplement as this study is testing how a supplement influences a variety of psychological outcomes
* Participants must be on the hormonal birth control pill for at least six months as participants who have been on the pill for less than 6 months may not be experiencing nutritional depletion yet
* If the investigators are able to do so, the investigators will only recruit participants who take the one-month hormonal birth control pill rather than the three month hormonal birth control pill, as the investigators are going to have participants come in after 28 days (day 2 of pack 1 and day 2 of pack 2) and participants on the three-month HBC pill may be on a 21 day cycle.
* Participants must have no food or medication allergies that will prevent the participants from safely taking the supplement
* Participants must not be taking any vitamins or participant must report willingness to abstain from taking vitamins during the study as individuals who are already taking vitamins may not be experiencing nutritional depletion associated with hormonal birth control
* If the investigators have the ability to do so, the investigators will only recruit…
Questions worth asking your doctor
Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.
1Based on my diagnosis and history, is this trial worth exploring for me — or is there a standard treatment we should try first?
2What does this trial's phase tell us about how much is already known about its safety and benefit?
3What would taking part actually involve for me — visits, tests, time, and travel?
4What are the known and possible risks or side effects I should weigh, and how would they be monitored?
5If this trial isn't the right fit, what other options or trials would you suggest I look into?
Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.
Questions for the trial coordinator
The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.
1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?
A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.
What they're measuring
1
Change from Baseline in Levels of Perceived Vulnerability to Disease Scale after 1 Month of Drug Usage
Timeframe: From day 1 of supplement usage to the end of treatment at 4 weeks.
2
Change from Baseline in Levels of Happiness after 1 Month of Drug Usage
Timeframe: From day 1 of supplement usage to the end of treatment at 4 weeks.
3
Change from Baseline in Levels of Digestive Health after 1 Month of Drug Usage
Timeframe: From day 1 of supplement usage to the end of treatment at 4 weeks.
4
Change from Baseline in Levels of Mood Swings after 1 Month of Drug Usage
Timeframe: From day 1 of supplement usage to the end of treatment at 4 weeks.
5
Change from Baseline in Levels of Energy after 1 Month of Drug Usage
Timeframe: From day 1 of supplement usage to the end of treatment at 4 weeks.