RecruitingPhase 2

Study to Assess the Effects of Angiopoietin-like Protein 3 (ANGPTL3) Inhibition in Adult Participants With Diabetic Kidney Disease

United States270 participantsStarted 2026-01-09

Plain-language summary

This study is researching experimental drugs called ALN-ANG3 and evinacumab (called "study drugs"). The study is focused on participants who have diabetic kidney disease. The aim of the study is to see how safe and effective the study drugs are. The study is looking at several other research questions, including: * What side effects may happen from taking the study drug * How much study drug is in the blood at different times

Who can participate

Age range18 Years – 80 Years

SexALL

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Inclusion criteria

✓. Medical history of type 2 diabetes and receiving medical therapy or lifestyle interventions for glucose management
✓. Hemoglobin A1C (HbA1c) of 6.5 to 10% at screening
✓. eGFR 30 to 90 mL/min/1.73 m\^2 using 2021 Chronic Kidney Disease-Epidemiology Collaboration-Estimated Glomerular Filtration Rate using Creatinine and Cystatin C (CKD-EPI eGFRcr-cys) equation at screening
✓. Albuminuria: Urine Albumin to Creatinine Ratio (UACR) of 500 to 5000 mg/g at screening

Exclusion criteria

✕. Known medical history or clinical evidence indicative of non-diabetic renal disease
✕. Renal disease that required treatment with systemic immunosuppressive therapy, or a history of dialysis or renal transplant
✕. Medically unstable as assessed by the investigator
✕. Hospitalization (ie, \>24 hours) within 30 days of the screening visit

What they're measuring

Percent change in Urine Albumin to Creatinine Ratio (UACR)

Timeframe: Baseline to Week 24

Trial details

NCT IDNCT07271186

SponsorRegeneron Pharmaceuticals

Sponsor typeINDUSTRY

Study typeINTERVENTIONAL

Primary completion2027-09-24

Contact for this trial

Clinical Trials Administrator

844-734-6643 clinicaltrials@regeneron.com

View on ClinicalTrials.gov More Diabetic Kidney Disease (DKD) trials