CompletedNot Applicable

Evaluation of Mechanical Power and Ventilator Parameters to Predict Weaning Success in the Intensive Care Unit

Turkey (Türkiye)60 participantsStarted 2025-07-01

Plain-language summary

The goal of this prospective observational study is to evaluate whether ventilator-based respiratory parameters can predict weaning success in adult intensive care unit (ICU) patients who are mechanically ventilated. The main questions it aims to answer are: Can the mechanical power (MP) value predict successful extubation? Do other respiratory parameters-airway occlusion pressure (P0.1), negative inspiratory force (NIF), and the rapid shallow breathing index (RSBI)-provide additional prognostic value for weaning outcomes? Participants will: * Be adult ICU patients planned for weaning from mechanical ventilation. * Undergo bedside ventilatory assessment within 2 hours after meeting clinical weaning criteria. * Have the following respiratory parameters measured: MP, P0.1, NIF, and RSBI. * Be monitored for 48 hours after extubation to assess weaning success (defined as no need for reintubation after extubation)

Who can participate

Age range

18 Years

Sex

ALL

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria: \- Age ≥ 18 years (adult patient population) * Patients receiving invasive mechanical ventilation in the intensive care unit * Having been intubated for at least 24 hours * Patients for whom the clinical team has decided extubation and who meet the following weaning criteria: * Stable respiratory parameters (FiO₂ ≤ 50%, PEEP ≤ 7 cmH₂O, SpO₂ ≥ 92%) * Hemodynamic stability (no inotropic support or minimal/stable dose) * Stable acid-base balance * Adequate secretion control * Technically suitable ventilator and measurement conditions * Written informed consent obtained from the patient or legal representative Exclusion Criteria: * Patients with any of the following conditions will be excluded: and * Individuals under 18 years of age * Pregnant patients * Patients who do not meet the weaning criteria * Tracheostomized patients * Neuromuscular diseases (e.g., Guillain-Barré syndrome, Duchenne muscular dystrophy, etc.) * Technical inadequacy preventing correct ventilator measurements * Significant asynchrony (e.g., auto-PEEP, double triggering, ineffective triggering, cycle asynchrony, auto-triggering) * Patients without an extubation plan or those receiving palliative care * RASS ≤ -2 (excessive sedation) for PSV mode measurements * RASS ≥ +2 (agitation) for PSV-CPAP mode measurements * Patients with delirium for PSV-CPAP mode measurements * Patients who cannot provide consent, have no legal representative, or whose representative refuses consent

Questions worth asking your doctor

Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.

1Based on my diagnosis and history, is this trial worth exploring for me — or is there a standard treatment we should try first?
2What does this trial's phase tell us about how much is already known about its safety and benefit?
3What would taking part actually involve for me — visits, tests, time, and travel?
4What are the known and possible risks or side effects I should weigh, and how would they be monitored?
5If this trial isn't the right fit, what other options or trials would you suggest I look into?

Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.

Questions for the trial coordinator

The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.

1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?

A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.

What they're measuring

Mechanical Power (MP)

Timeframe: 48 hour

Trial details

NCT IDNCT07268989

SponsorAnıl Berkay Balıtatlı

Sponsor typeOTHER

Study typeOBSERVATIONAL

Primary completion2026-04-07

View on ClinicalTrials.gov More Weaning Mechanical Ventilation trials