Not Yet RecruitingNot Applicable

1-hour Premedication for Allergy Goal in Emergency: PAGE-1 Study

540 participantsStarted 2026-06

Plain-language summary

1-hour Premedication for Allergy Goal in Emergency: PAGE-1 is a prospective, parallel, two-arm, non-inferiority, randomized controlled trial evaluating the safety of a 1-hour (intervention) versus a 4-hour (standard regimen) intravenous (IV) premedication protocol in adult patients in the Emergency Department (ED) with a documented iodinated contrast allergy and requiring computed tomography (CT) imaging for a high-risk indication.

Who can participate

Age range21 Years

SexALL

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Inclusion criteria

✓. Adult (≥ 21 years old)
✓. Documented iodinated contrast allergy in the electronic health record
✓. CT with iodinated contrast ordered for a high-risk indication, † defined as post-arrest, concern for aortic dissection, ischemia, occlusion, obstruction, or other life-threatening conditions requiring timely diagnosis
✓. Willing and able to give consent

Exclusion criteria

✕. Previous enrollment in this study
✕. Pregnancy
✕. Seafood or iodine allergy, alone
✕. Gadolinium allergy

What they're measuring

Difference in proportion of Acute Contrast Reaction

Timeframe: 30 minutes

Proportion of patients eligible for intervention

Timeframe: Before randomization

Trial details

NCT IDNCT07268248

SponsorPaul Peng, MD PhD MSCR

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2027-12

Contact for this trial

Chirag N Shah, MD

732-235-8717 shahcn@rwjms.rutgers.edu

View on ClinicalTrials.gov More Allergic Reaction to Contrast Media trials