This study aims to retrospectively compare two different multimodal analgesic techniques for pain management after total knee arthroplasty (TKA). The primary purpose is to evaluate whether a combination of two specific nerve blocks administered by an anesthesiologist (Femoral Triangle Block + iPACK block) resulted in superior postoperative pain control compared to a hybrid combination of a nerve block and a local infiltration administered by the surgeon (FTB + Periarticular Infiltration \[PAI\]).
The hypothesis is that the FTB + iPACK combination is associated with a significant reduction in Numeric Rating Scale (NRS) pain scores with movement at 24 hours postoperatively. This is a retrospective, observational cohort study conducted at a single center, involving medical records of patients who underwent primary unilateral TKA. Data from patients who received either FTB + iPACK or FTB + PAI as part of their standard clinical care will be extracted and analyzed retrospectively.
Who can participate
Age range
18 Years – 80 Years
Sex
ALL
See this in plain English?
AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
Inclusion Criteria:
* American Society of Anesthesiologists (ASA) physical status II-III.
* Scheduled for elective, primary, unilateral total knee arthroplasty for osteoarthritis.
* Able to provide written informed consent.
Exclusion Criteria:
* Patient refusal to participate or contraindication to regional anesthesia.
* Known allergy to any study medications (local anesthetics, NSAIDs, tramadol, morphine, paracetamol).
* History of chronic opioid use (defined as daily use for \>3 months)
* Pre-existing peripheral neuropathy in the operative limb.
* Severe renal or hepatic insufficiency.
* Cognitive impairment preventing the use of pain scales or questionnaires.
* Revision or bilateral knee arthroplasty.
Questions worth asking your doctor
Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.
1This trial compares two nerve-blocking techniques — the iPACK block and periarticular infiltration — for pain control after knee replacement; can you explain which of these approaches you currently use in your practice and how that might affect whether this trial is a good fit for me?
2Since this trial is listed as 'not yet recruiting,' how much of a delay might that mean before I could potentially participate, and would waiting affect my knee replacement timeline or my osteoarthritis progression?
3The trial's main goal is measuring pain with movement at 24 hours after surgery — does that mean there's less data collected on longer-term pain relief or recovery, and is that something I should factor into my decision?
4Because this is listed as Phase N/A, what does that tell us about what's already known or unknown about the safety and effectiveness of these two pain control methods compared to each other?
5If I'm not eligible for or don't want to join this trial, what pain control approach would you recommend for my knee replacement surgery as a standard-of-care alternative?
Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.
Questions for the trial coordinator
The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.
1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?
A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.
What they're measuring
1
Postoperative Pain Score with Movement at 24 Hours