Unravelling the Measles Paradox (MISIA) (NCT07267585) | Clinical Trial Compass
RecruitingNot Applicable
Unravelling the Measles Paradox (MISIA)
Netherlands300 participantsStarted 2025-07-03
Plain-language summary
The measles (MeV) paradox refers to an apparent contradiction: natural measles causes a transient but profound immune suppression putting patients at risk for opportunistic infections for years, while at the same time MeV infection induces robust immune activation leading to lifelong protection against measles. In this protocol, we test our hypothesis that natural measles causes immune amnesia by altering the composition of circulating immune memory cells. In comparison to the prior studies performed during the 2013 outbreak, we will specifically determine \[1\] to what extent pre-existing immunity is reduced, \[2\] for how long this functional immune suppression can be detected, and \[3\] to what extent MeV-specific immune cells expand.
Recently, the WHO reported a 30-fold increase of the number of measles cases in the European Region in 2023 and the ECDC has published a threat assessment brief on increase of the number of cases and considerations for public health response. Combined with the reported drop in vaccination coverage, and several clusters of cases, we anticipate that we are at the verge of a new measles outbreak in the Netherlands
Who can participate
Age range
18 Years
Sex
ALL
See this in plain English?
AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
Inclusion Criteria:
Cohort A
* 18 years or older
* No known history of measles or vaccination
* Decided to take MMR vaccination before the upcoming measles outbreak
Cohort B
* 18 years or older
* No known history of measles or vaccination (seronegative confirmed)
* Contracted measles during the upcoming outbreak
Cohort C
* 18 years or older
* No known history of measles or vaccination (seronegative confirmed)
Cohort D
* 18 years or older
* Experienced measles during the 2013 outbreak
Cohort E
* 18 years or older
* Received second dose of measles vaccines ±10 years ago
Exclusion Criteria:
A potential participant who meets any of the following criteria will be excluded from the study:
* Diagnosed chronic disease
* Immune suppression (due to medication or underlying disease)
* Additionally for subjects recruited to Cohort A:
* pregnant women or women planning to get pregnant in less than one month after the start of the study. This is a precaution; the MMR vaccine is not recommended for pregnant women.
* People who have had a severe allergic reaction (e.g., anaphylaxis) after a previous vaccination.
Questions worth asking your doctor
Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.
1Based on my diagnosis and history, is this trial worth exploring for me — or is there a standard treatment we should try first?
2What does this trial's phase tell us about how much is already known about its safety and benefit?
3What would taking part actually involve for me — visits, tests, time, and travel?
4What are the known and possible risks or side effects I should weigh, and how would they be monitored?
5If this trial isn't the right fit, what other options or trials would you suggest I look into?
Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.
Questions for the trial coordinator
The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.
1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?
A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.
What they're measuring
1
Compare measles-induced loss of pathogen-specific antibodies
Timeframe: 36 months
2
Compare measles-induced loss of pathogen-specific T-cells