CompletedNot Applicable

Effect of a Mouthwash Containing Chlorhexidine and Chlorine Dioxide on Halitosis

Vietnam40 participantsStarted 2023-09-05

Plain-language summary

Halitosis significantly impacts the quality of a patient's life. This randomized, double-blind crossover trial evaluates a mouthwash containing chlorhexidine (0.01%) and chlorine dioxide (0.05%) compared with placebo. Forty participants rinsed twice daily for 2 weeks, followed by a 2-week washout and crossover. The primary outcomes were volatile sulfur compounds (H₂S, CH₃SH), measured by OralChroma. Secondary outcomes included plaque index, gingival index, bleeding on probing, tongue coating, and salivary bacterial counts (Aa, Pg, Fn, Pi, and Ec).

Who can participate

Age range18 Years – 65 Years

SexALL

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AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria: * ≥20 natural teeth * H₂S \>1.5 ng/10ml or CH₃SH \>0.5 ng/10ml * Signed informed consent Exclusion Criteria: * Systemic disease * Smoking * Pregnancy or lactation * Periodontal pockets ≥4 mm * Recent antibiotic use (\<1 month) * Orthodontic appliances or dentures * Allergy to CHX or C

What they're measuring

Change in Hydrogen sulfide (H₂S) concentration in breath

Timeframe: baseline, immediate post-rinse, 2 weeks

Change in Methyl mercaptan (CH₃SH) concentration in breath

Timeframe: Baseline, immediate post-rinse, 2 weeks

Trial details

NCT IDNCT07265102

SponsorCan Tho University of Medicine and Pharmacy

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2023-12-05

View on ClinicalTrials.gov More Halitosis trials