RecruitingNot Applicable

PRIOR Study (Pre-eclampsia Risk In Oocyte Recipients)

Denmark462 participantsStarted 2024-10-21

Plain-language summary

The aim of this prospective observational cohort study is to investigate the pathophysiological mechanisms behind and risk of pre-eclampsia in women pregnant after fertility treatment with oocyte donation. The participants are included in of of two cohorts. One includes women pregnant after oocyte donation whereas the other includes women pregnant after IVF treatment with autologous oocytes. Participants will be followed throughout pregnancy with blood samples, blood pressure, clinical controls and ultrasound examinations. Clinical outcomes will be registered post-partum.

Who can participate

Age range18 Years

SexFEMALE

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AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria: * Age \> 18 years * BMI \< 35 kg/m2 * Normal wet smear within the past three years * Both nulli- and multiparous * Singletons and multiple gestations Exclusion Criteria: * Age \< 18 years * BMI \> 35 kg/m2 * HIV/ hepatitis * Essential hypertension * Chronic kidney disease * Undiagnosed vaginal bleeding * Uterine malformations * Persisting ovarian cysts * Tumors in hypothalamus, pituitary, thyroid, or adrenal glands. * Previous breast cancer * Known BRCA 1 or 2 gene * Unregulated thyroid disease * Cardiovascular disease * Breast feeding * Present or previous chemotherapy/radiation therapy * Present or previous malignant disease * Smoking * Alcohol/drug abuse

What they're measuring

Pre-eclampsia

Timeframe: During pregnancy and in the following two weeks post-partum

Biochemical markers for pre-eclampsia

Timeframe: From early pregnancy untill delivery

Trial details

NCT IDNCT07263490

SponsorCopenhagen University Hospital, Hvidovre

Sponsor typeOTHER

Study typeOBSERVATIONAL

Primary completion2027-10-31

View on ClinicalTrials.gov More Pre-eclampsia trials