Active — Not RecruitingPhase 2

N-acetylcysteine for Root Canal Treatment of Necrotic Teeth With Apical Periodontitis

Egypt40 participantsStarted 2025-11-15

Plain-language summary

A randomized controlled trial comparing the postoperative pain intensity, periapical biomarkers level, and periapical healing in patients with necrotic mature teeth and apical periodontitis treated with N-acetylcysteine (NAC), as an intracanal and adjunctive systemic medication, versus calcium hydroxide (Ca(OH)₂) intracanal medication alone.

Who can participate

Age range16 Years – 60 Years

SexALL

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria: * Mature necrotic teeth. * Radiographic evidence of periapical bone loss. * Teeth that require primary endodontic treatment. * Restorable teeth. Exclusion Criteria: * Immature teeth * Teeth that had been previously accessed or endodontically treated. * Teeth with periodontal pockets deeper than 4 mm. * Patients with acute apical abscess. * Patients with systemic diseases. * Pregnant females. * Patients who received antibiotic therapy within the past month. * Patient on analgesics.

What they're measuring

Postoperative pain intensity

Timeframe: Pain will be recorded before the intervention, and patients will use the Numerical Rating Scale (NRS) to self-assess postoperative pain at 6 hours, 12 hours, 24 hours, 48 hours, 72 hours, and 1 week.

Assessment of periapical healing

Timeframe: A CBCT scan will be taken preoperatively and at six months follow-up.

Trial details

NCT IDNCT07262554

SponsorAlexandria University

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2026-06

View on ClinicalTrials.gov More Apical Periodontitis trials