The Effects of Coenzyme Q10 Pretreatment on Ovarian Function and Assisted Reproductive Outcomes in Patients With Ovarian Hyporesponsiveness.

Inclusion Criteria: * Individuals seeking IVF-ET fertility treatment; * Meeting the Bologna criteria for the definition of poor ovarian response (POR), specifically: * (1) Meeting 2 of the following 3 criteria: * ① Presence of high-risk factors for POR; * ② Previous cycle with ≤3 retrieved oocytes under a standard stimulation protocol; * ③ Abnormal ovarian reserve assessment: Antral follicle count (AFC) \<5 or Anti-Müllerian hormone (AMH) \<1.1 ng/mL. or * (2) Patients with normal age or ovarian reserve function who experience poor ovarian response (POR) after two consecutive cycles of maximum ovarian stimulation protocols; * BMI between 18.5-28.0 kg/m² * Voluntarily participate and sign an informed consent form. Exclusion Criteria: * Age ≥40 years; * Baseline FSH \>25 U/L; * Endocrine disorders (e.g., diabetes, thyroid disease) or autoimmune diseases (e.g., rheumatoid arthritis, lupus, Crohn's disease), chromosomal abnormalities, uterine malformations; * History of ovarian surgery; history of uterine surgery; adenomyosis; * History of more than 3 cycles of controlled ovarian stimulation (COS); * Male infertility; * Use within the past 3 months of medications that may affect ovarian reserve or ovarian responsiveness (e.g., oral contraceptives, glucocorticoids, antioxidant supplements, insulin sensitizers, DHEA, growth hormone, etc.); * Use of traditional Chinese medicine within the past 3 months; * Known allergy to Coenzyme Q10 or panthenol (water-soluble isomer of CoQ10…