CompletedNot Applicable

Associations of Postoperative Delirium With Perioperative Frailty Worsening and Their Combined Effect on 1-Year Mortality in Older Surgical Patients

China6,196 participantsStarted 2020-04-01

Plain-language summary

Postoperative delirium (POD) is a frequent complication in older surgical patients and is associated with adverse outcomes, while frailty is also highly prevalent during the perioperative period. This study aimed to determine whether POD accelerates perioperative frailty worsening and to assess the effect of their coexistence on 1-year mortality.

Who can participate

Age range65 Years

SexALL

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion criteria

✓. Aged ≥65 years;
✓. Scheduled for elective non-cardiac, non-neurosurgical procedures;
✓. Consented to undergo preoperative health and functional state assessments.

Exclusion criteria

✕. Had severe dementia, language disorders, significant hearing or visual impairments, or were in a coma;
✕. Had Mini-Mental State Examination (MMSE) scores below the established educational thresholds: \<18 for illiterate individuals, \<21 for those with primary education (≤6 years), and \<25 for those with secondary education or higher (\>6 years)
✕. Underwent local anesthesia or monitored anesthesia care;
✕. Had an operative time ≤30 minutes;
✕. Incomplete preoperative FRAIL scale assessment;
✕. Missing postoperative delirium data;
✕. Incomplete FRAIL scale assessment at 1 month postoperatively.

What they're measuring

The primary outcome was worsened frailty at one month after surgery.

Timeframe: At one month after surgery.

Trial details

NCT IDNCT07259850

SponsorChinese PLA General Hospital

Sponsor typeOTHER

Study typeOBSERVATIONAL

Primary completion2022-04-30

View on ClinicalTrials.gov More Postoperative Delirium (POD) trials