RecruitingNot Applicable

Effect of VExUS Ultrasound Protocol (Venous Excess Ultrasound) on Perioperative Fluid Management, on the Incidence of Postoperative Pulmonary Complications and Postoperative Acute Kidney Injury in Patients Undergoing Thoracic Surgery

Greece230 participantsStarted 2024-11-27

Plain-language summary

This study aims to investigate the effect of a VExUS ultrasound guided protocol of perioperative fluid management within a goal-directed therapy framework, on postoperative respiratory complications, and the occurrence of acute kidney injury (AKI) in patients undergoing thoracic surgery.

Who can participate

Age range18 Years

SexALL

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria: * Adults \>18 years undergoing video assisted thoracic surgery/ lobectomy requiring one-lung ventilation. Exclusion Criteria: * Refusal to participate. * Pneumonectomy. * Young athletes (risk of physiologically large IVC \>2 cm). * Moderate-severe tricuspid regurgitation, moderate to severe pulmonary hypertension * Heart failure with reduced ejection fraction, EF\<35% * Portal hypertension, portal vein thrombosis, or liver cirrhosis. * Stage 4 or end-stage chronic kidney disease (eGFR \<30 mL/min/1.73 m² or dialysis). * Transfusion with more than 2 packed red blood cells unit perioperatively (intraoperatively, in the PACU, in the ward)

What they're measuring

Kidney function-estimated glomerular filtration rate preoperatively

Timeframe: preoperatively

Kidney function-estimated glomerular filtration rate in the PACU

Timeframe: in the PACU

Kidney function- estimated glomerular filtration rate on postoperative day 1

Timeframe: postoperative day 1

Kidney function-estimated glomerular filtration rate on postoperative day 3

Timeframe: on postoperative day 3

Urine output intraoperatively

Timeframe: From anesthesia induction, until the end of surgery

Urinary output postoperatively in the PACU

Timeframe: during the PACU stay

Renal stress biomarkers TIMP-2,IGFBP-7

Timeframe: postoperatively in the PACU

Serum Creatinine preoperatively

Timeframe: preoperatively

Trial details

NCT IDNCT07258875

SponsorUniversity of Crete

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2028-11-01

Contact for this trial

Alexandros Bogas Manouselis, Resident of Anaesthesiology

+306947545446 bogas.alexandros@gmail.com

View on ClinicalTrials.gov More Thoracic Surgery With One-lung Ventilation trials

Who can participate

Age range18 Years

SexALL

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

What they're measuring

Kidney function-estimated glomerular filtration rate preoperatively

Timeframe: preoperatively

Kidney function-estimated glomerular filtration rate in the PACU

Timeframe: in the PACU

Kidney function- estimated glomerular filtration rate on postoperative day 1

Timeframe: postoperative day 1

Kidney function-estimated glomerular filtration rate on postoperative day 3

Timeframe: on postoperative day 3

Urine output intraoperatively

Timeframe: From anesthesia induction, until the end of surgery

Urinary output postoperatively in the PACU

Timeframe: during the PACU stay

Renal stress biomarkers TIMP-2,IGFBP-7

Timeframe: postoperatively in the PACU

Serum Creatinine preoperatively

Timeframe: preoperatively