the Effectiveness of Continuous Compression-synchronous Ventilation (Bio-CPR) (NCT07258823) | Clinical Trial Compass
Not Yet RecruitingNot Applicable
the Effectiveness of Continuous Compression-synchronous Ventilation (Bio-CPR)
408 participantsStarted 2026-02-01
Plain-language summary
Bio-CPR is an innovative new mechanical resuscitation model proposed by our research group. A multi-center RCT study was established to comprehensively evaluate the efficacy of this model and the current standard CPR protocol, verify its safety and efficacy, and provide high-quality clinical evidence support.
Who can participate
Age range
18 Years – 75 Years
Sex
ALL
See this in plain English?
AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
Inclusion criteria
. 18-65 years old; 2. Cardiac arrest with witnesses; 3. Onset - compression start time\<5 minutes; 4. Initial ventricular fibrillation rhythm; 5. Endotracheal intubation and use of a mechanical chest CPR device; Patients with OHCA who meet the above conditions
Questions worth asking your doctor
Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.
1This trial is studying a technique called Bio-CPR, which delivers breaths in sync with chest compressions continuously — how does that differ from the standard CPR approach my loved one would receive, and could it change their care in an emergency?
2Since this trial is not yet recruiting, how soon might it open, and is there another way my loved one could access newer CPR approaches in the meantime?
3The trial is measuring mean tidal volume — which is basically how much air gets into the lungs during CPR — why does that matter for survival or brain outcomes after cardiac arrest, and is it something I should be paying attention to?
4This study focuses on out-of-hospital cardiac arrest, which by definition happens before hospital care begins — does that mean the intervention would involve paramedics or first responders, and how would that affect what happens if my loved one needs emergency care?
5Since this trial is listed as Phase NA, meaning it may be more of an observational or device study without the usual drug-trial phase structure, what does that tell us about how much safety and benefit data already exists for Bio-CPR compared to standard resuscitation?
Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.
Questions for the trial coordinator
The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.
1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?
A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.