Submucosal Dexamethasone for Control of Post-operative Pain, Trismus, and Swelling After Mandibul… (NCT07258498) | Clinical Trial Compass
CompletedPhase 4
Submucosal Dexamethasone for Control of Post-operative Pain, Trismus, and Swelling After Mandibular Third Molar Surgery
Pakistan70 participantsStarted 2024-10-01
Plain-language summary
Purpose: The aim of this study is to determine the efficacy of submucosal injection of dexamethasone in reducing pain, swelling and trismus, thus to minimize patient's discomfort after surgery, so that the patients could pursue their daily activities without delay. Moreover, the submucosal injection is convenient to the patient and surgeon both, as it is injected after application of local anesthesia and easily administered. OBJECTIVES: To evaluate the outcome of submucosal injection of 4mg/ml dexamethasone in comparison with submucosal injection of normal saline (N/S) on mean post-operative pain, trismus and swelling following mandibular third molar surgery.
Who can participate
Age range
18 Years – 45 Years
Sex
ALL
See this in plain English?
AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
Inclusion Criteria:
* Cases of impacted mandibular third molar according to Pell and Gregory classification (class l, 2. 3 and A. B, C)
* Both genders (male and female)
* Age limit: 18 - 45 years
Exclusion Criteria:
* Patients with pericoronitis.
* Patients with known allergy to corticosteroids.
* Medically compromised patients.
* Current pregnancy.
* Lactating women.
* Use of medication by the patients that could interfere with the healing process.
Questions worth asking your doctor
Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.
1Based on my diagnosis and history, is this trial worth exploring for me — or is there a standard treatment we should try first?
2What does this trial's phase tell us about how much is already known about its safety and benefit?
3What would taking part actually involve for me — visits, tests, time, and travel?
4What are the known and possible risks or side effects I should weigh, and how would they be monitored?
5If this trial isn't the right fit, what other options or trials would you suggest I look into?
Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.
Questions for the trial coordinator
The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.
1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?
A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.
What they're measuring
1
measurement of post-operative pain, in patients who have undergone surgery for impacted mandibular third molars.
Timeframe: from enrolment to 7th post operative day
2
measurement of post-operative trismus in patients who have undergone surgery for impacted mandibular third molars.
Timeframe: From enrollment to the 7th Postoperative day
3
measurement of post-operative swelling in patients who have undergone surgery for impacted mandibular third molars.
Timeframe: from enrolment to 7th post operative day