Dopamine and Insulin in Psychosis

Inclusion Criteria: All participants * age 18-40 * Body mass index (BMI) range 18-25 * good general health according to physical examination and medical history * absence of relevant abnormalities in laboratory screening, electrocardiogram (ECG) or vital signs * no regular use of drugs of abuse or alcohol based on history and urine drug screen Patients only * diagnosis of schizophrenia or schizophreniform disorder according to DSM-5 * ability to give informed consent * minimum Positive and Negative Syndrome Scale (PANSS) score of 55 with \>3 on at least two or \>4 on one PANSS psychosis item Exclusion Criteria: All participants * severe or unstable medical or neurological illness or clinically significant abnormality on screening laboratory studies or ECG * established diagnosis of type 1 or type 2 diabetes * current substance use disorder or regular recreational drug abuse (except nicotine and caffeine) * pregnancy or breastfeeding * history of head trauma resulting in loss of consciousness of \>1min or requiring medical attention * presence of MRI exclusion criteria * if participation in this study would exceed annual radiation dose limits (30mSv) * clinically established diagnosis of intellectual disability Healthy volunteers only * Psychiatric disorder according to Mini-International Neuropsychiatric Interview (M.I.N.I.) * Schizophrenia or bipolar disorder in first degree family members Patients only ● Previous oral antipsychotic treatment for more than 2 weeks…