Not Yet RecruitingNot Applicable

Diagnostic Value of EBUS-Guided Transbronchial Mediastinal Cryobiopsy Versus Conventional Bronchoscopic Approaches for Stage I/II Sarcoidosis

469 participantsStarted 2026-03-01

Plain-language summary

Endobronchial ultrasound-guided transbronchial needle aspiration (EBUS-TBNA), combined with endobronchial biopsy (EBB) and/or transbronchial lung biopsy (TBLB), and endobronchial ultrasound-guided transbronchial mediastinal cryobiopsy (EBUS-TBMC) have high diagnostic yields for patients with sarcoidosis. However, a direct comparison between them has not been conducted. This randomized controlled trial aims to compare directly the diagnostic yield between EBUS-TBMC and EBUS-TBNA+EBB+TBLB in sarcoidosis.

Who can participate

Age range18 Years

SexALL

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion criteria

✓. Age ≥18years;
✓. Patients with clinical and radiological suspicion of stage I or stage II sarcoidosis;
✓. Fully informed of the purpose and method of the study

Exclusion criteria

✕. Pathologically confirmed sarcoidosis, obvious organ involvement with the possibility of confirming granulomas using a minimally invasive diagnostic procedure;
✕. Patients with medical contraindications to bronchoscopy procedures.

What they're measuring

The granuloma detection rate

Timeframe: 7 days after sampling

Trial details

NCT IDNCT07246876

SponsorChina-Japan Friendship Hospital

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2026-11-01

View on ClinicalTrials.gov More Sarcoidosis, Pulmonary trials