RecruitingNot Applicable

Pistachio Intake and Nutrition-Related Outcomes in Individuals on GLP-1 Therapy

United States108 participantsStarted 2026-01-29

Plain-language summary

In this study will look at how eating pistachios every day might affect participants weight, how healthy their diet is, and how they feel when eating. Investigators want to see if adding pistachios to meals for 12 weeks helps participants feel fuller, have more energy, and improve body composition. The study will include adults who have been taking GLP-1 medicines like semaglutide or tirzepatide for at least three months. Investigators also want to see if eating pistachios improves overall diet quality and health markers like tiredness and certain levels in blood.

Who can participate

Age range18 Years – 80 Years

SexALL

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria: * Individuals with a BMI ≥30 kg/m2 or with a BMI ≥27 kg/m2 with at least one weight-related comorbidity who have been continuously using semaglutide or tirzepatide for three months for a clinical indication and remain on the therapy at the time of enrollment Exclusion Criteria: * No use or contraindication to use of a GLP-1 RA * Known allergy to nuts * Pregnant or breastfeeding * Incarcerated

What they're measuring

Change is Satiety as measured by the Hunger and Satiety Visual Analog Scales (VAS)

Timeframe: Baseline, End of study (12 weeks)

Change in fatigue as measured by the Fatigue Severity VAS-F Survey

Timeframe: Baseline, End of study (12 weeks)

Change in mood/well-being as measured by the Mental clarity, energy levels, and motivation VAS.

Timeframe: Baseline, End of study (12 weeks)

Change in dietary quality as measured by Healthy Eating Index (HEI)

Timeframe: Baseline, End of study (12 weeks)

Change in food enjoyment as measured by the Food Pleasure Scale (FPS)

Timeframe: Baseline, End of study (12 weeks)

Change in fasting glucose as measured by medical record review

Timeframe: Baseline, End of study (12 weeks)

Change in HbA1c as measured by medical record review

Timeframe: Baseline, End of study (12 weeks)

Trial details

NCT IDNCT07244445

SponsorIan J. Neeland, MD

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2027-12

Contact for this trial

Ian Neeland, MD

216-844-5965 Ian.Neeland@UHhospitals.org

View on ClinicalTrials.gov More Dietary Change trials

Plain-language summary

Who can participate

Age range18 Years – 80 Years

SexALL

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

What they're measuring

Change is Satiety as measured by the Hunger and Satiety Visual Analog Scales (VAS)

Timeframe: Baseline, End of study (12 weeks)

Change in fatigue as measured by the Fatigue Severity VAS-F Survey

Timeframe: Baseline, End of study (12 weeks)

Change in mood/well-being as measured by the Mental clarity, energy levels, and motivation VAS.

Timeframe: Baseline, End of study (12 weeks)

Change in dietary quality as measured by Healthy Eating Index (HEI)

Timeframe: Baseline, End of study (12 weeks)

Change in food enjoyment as measured by the Food Pleasure Scale (FPS)

Timeframe: Baseline, End of study (12 weeks)

Change in fasting glucose as measured by medical record review

Timeframe: Baseline, End of study (12 weeks)

Change in HbA1c as measured by medical record review

Timeframe: Baseline, End of study (12 weeks)