RecruitingNot Applicable

Pistachio Intake and Nutrition-Related Outcomes in Individuals on GLP-1 Therapy

United States108 participantsStarted 2026-01-29

Plain-language summary

In this study will look at how eating pistachios every day might affect participants weight, how healthy their diet is, and how they feel when eating. Investigators want to see if adding pistachios to meals for 12 weeks helps participants feel fuller, have more energy, and improve body composition. The study will include adults who have been taking GLP-1 medicines like semaglutide or tirzepatide for at least three months. Investigators also want to see if eating pistachios improves overall diet quality and health markers like tiredness and certain levels in blood.

Who can participate

Age range

18 Years – 80 Years

Sex

ALL

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria: * Individuals with a BMI ≥30 kg/m2 or with a BMI ≥27 kg/m2 with at least one weight-related comorbidity who have been continuously using semaglutide or tirzepatide for three months for a clinical indication and remain on the therapy at the time of enrollment Exclusion Criteria: * No use or contraindication to use of a GLP-1 RA * Known allergy to nuts * Pregnant or breastfeeding * Incarcerated

Questions worth asking your doctor

Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.

1Based on my diagnosis and history, is this trial worth exploring for me — or is there a standard treatment we should try first?
2What does this trial's phase tell us about how much is already known about its safety and benefit?
3What would taking part actually involve for me — visits, tests, time, and travel?
4What are the known and possible risks or side effects I should weigh, and how would they be monitored?
5If this trial isn't the right fit, what other options or trials would you suggest I look into?

Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.

Questions for the trial coordinator

The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.

1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?

A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.

What they're measuring

Change is Satiety as measured by the Hunger and Satiety Visual Analog Scales (VAS)

Timeframe: Baseline, End of study (12 weeks)

Change in fatigue as measured by the Fatigue Severity VAS-F Survey

Timeframe: Baseline, End of study (12 weeks)

Change in mood/well-being as measured by the Mental clarity, energy levels, and motivation VAS.

Timeframe: Baseline, End of study (12 weeks)

Change in dietary quality as measured by Healthy Eating Index (HEI)

Timeframe: Baseline, End of study (12 weeks)

Change in food enjoyment as measured by the Food Pleasure Scale (FPS)

Timeframe: Baseline, End of study (12 weeks)

Change in fasting glucose as measured by medical record review

Timeframe: Baseline, End of study (12 weeks)

Change in HbA1c as measured by medical record review

Trial details

NCT IDNCT07244445

SponsorIan J. Neeland, MD

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2027-12

Contact for this trial

Ian Neeland, MD

216-844-5965 Ian.Neeland@UHhospitals.org

View on ClinicalTrials.gov More Dietary Change trials

Plain-language summary

Who can participate

Age range

18 Years – 80 Years

Sex

ALL

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

What they're measuring

Change is Satiety as measured by the Hunger and Satiety Visual Analog Scales (VAS)

Timeframe: Baseline, End of study (12 weeks)

Change in fatigue as measured by the Fatigue Severity VAS-F Survey

Timeframe: Baseline, End of study (12 weeks)

Change in mood/well-being as measured by the Mental clarity, energy levels, and motivation VAS.

Timeframe: Baseline, End of study (12 weeks)

Change in dietary quality as measured by Healthy Eating Index (HEI)

Timeframe: Baseline, End of study (12 weeks)

Change in food enjoyment as measured by the Food Pleasure Scale (FPS)

Timeframe: Baseline, End of study (12 weeks)

Change in fasting glucose as measured by medical record review

Timeframe: Baseline, End of study (12 weeks)

Change in HbA1c as measured by medical record review