Comparative Efficacy of Rivaroxaban and Enoxaparin in Post-Laparotomy DVT Prevention (NCT07243080) | Clinical Trial Compass
RecruitingPhase 4
Comparative Efficacy of Rivaroxaban and Enoxaparin in Post-Laparotomy DVT Prevention
Pakistan212 participantsStarted 2025-10-10
Plain-language summary
The goal of this clinical trial is to learn if rivaroxaban works better than enoxaparin to prevent deep vein thrombosis (DVT) after emergency exploratory laparotomy in adults. It will also learn about the safety of rivaroxaban compared to enoxaparin.
The main questions it aims to answer are:
Does rivaroxaban lower the number of patients who develop DVT after exploratory laparotomy compared to enoxaparin?
What medical problems or side effects do participants have when taking rivaroxaban versus enoxaparin?
Researchers will compare rivaroxaban (an oral anticoagulant) to enoxaparin (a subcutaneous injection) to see which drug works better to prevent blood clots after surgery.
Participants will:
Take rivaroxaban 10 mg orally once daily for 7 days, or enoxaparin 40 mg subcutaneously once daily for 7 days after surgery
Undergo duplex color Doppler ultrasound scans of the legs on day 5 and day 10 after surgery
Be monitored for bleeding, complications, and other side effects
Who can participate
Age range
18 Years – 80 Years
Sex
ALL
See this in plain English?
AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
Inclusion Criteria:• Patients aged 18 to 80 years
* Both male or female patients
* Patients who have undergone emergent exploratory laparotomy for any reason whether traumatic or non-traumatic
* Patients with expected immobility for more than 24 hours
Exclusion Criteria:
* Patients with diagnosed pre-operative DVT
* BMI more than 40
* Patient who are on mechanical ventilation post operatively
* Patient with postoperative Myocardial infarction, ischemic heart disease or cerebrovascular accident
* Patients who have undergone limb surgery in addition to exploratory laparotomy
Questions worth asking your doctor
Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.
1Based on my diagnosis and history, is this trial worth exploring for me — or is there a standard treatment we should try first?
2What does this trial's phase tell us about how much is already known about its safety and benefit?
3What would taking part actually involve for me — visits, tests, time, and travel?
4What are the known and possible risks or side effects I should weigh, and how would they be monitored?
5If this trial isn't the right fit, what other options or trials would you suggest I look into?
Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.
Questions for the trial coordinator
The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.
1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?
A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.