Emerging Indications for Hyperbaric Oxygen Treatment
100 participantsStarted 2026-08
Plain-language summary
This study will evaluate the effectiveness of hyperbaric oxygen therapy (HBOT) on treating emerging indications (i.e., conditions that have shown to potentially benefit from HBOT) using the Multicenter Registry for Hyperbaric Oxygen Treatment. The study team aims to collect ongoing data on how well HBOT treats these emerging indications, and to add these data to the growing HBO Registry. The research team hypothesizes that HBOT will result in improvements of the condition of the various emerging indications.
Who can participate
Sex
ALL
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AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
Inclusion Criteria:
* Patients referred for HBOT with an emerging indication
Exclusion Criteria:
* Contraindication to hyperbaric oxygen treatment (untreated seizures, pneumothorax, significant pulmonary airspace pathology that might lead to pulmonary barotrauma, unmanageable confinement anxiety, chronic obstructive pulmonary disease with CO2 retention)
* Pregnant persons
Questions worth asking your doctor
Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.
1This trial covers a huge range of conditions — from post-COVID symptoms to Crohn's disease to frostbite — so given my specific diagnosis, does hyperbaric oxygen therapy make sense as something worth exploring for my particular situation, or is it still considered very experimental for my condition?
2Since this is a Phase 4 trial and the main thing being measured is quality of life using a questionnaire rather than a specific clinical cure, what does that tell us about what is and isn't yet known about whether HBO2 actually improves outcomes for my condition?
3The trial isn't recruiting yet — how long do you think it might be before it opens, and in the meantime, are there established or standard treatments I should be pursuing rather than waiting to see if I qualify?
4Hyperbaric oxygen therapy requires patients to spend time in a pressurized chamber, often for multiple sessions — given my current health and schedule, is that kind of treatment commitment realistic for me, and are there any medical reasons it could be risky in my case?
5Since this registry is collecting real-world outcomes across so many different conditions at once, how confident can we be that the findings will be meaningful specifically for my diagnosis, and is there a more focused trial or evidence base I should look at first?
Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.
Questions for the trial coordinator
The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.
1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?
A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.
What they're measuring
1
Quality of Life EuroQOL EQ-5D-5L Questionnaire
Timeframe: Within one week of starting HBO2 and within one week of ending HBO2 treatment