RecruitingNot Applicable

The Role and Regulatory Mechanism of Germinal Center Immune Response in Hepatitis B Virus Infection

China280 participantsStarted 2021-01-01

Plain-language summary

The purpose of this observational study is to investigate the structure and composition of germinal centers in individuals with chronic HBV infection. The primary questions it aims to address are: What are the phenotypes, functions, and complexity of B cell clones of the immune cells within the germinal centers of chronic HBV-infected individuals? Do chronic HBV-infected individuals have ectopic germinal centers in the liver? This will be studied by collecting peripheral blood and discarded liver, lymph node, and tonsil tissues from chronic HBV patients undergoing lymph node surgery, hepatectomy, and tonsillectomy.

Who can participate

Age range18 Years – 75 Years

SexALL

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Inclusion criteria

✓. Male or female, patients with chronic hepatitis B and hepatitis B surface antigen negative patients with clinical diagnosis who need to undergo liver, spleen, tonsil or lymph node surgery.
✓. Before performing any research-related steps, the patient understood the research process, signed the informed consent, and complied with the research requirements.
✓. Patients diagnosed with chronic hepatitis B virus infection according to the "Guidelines for the Prevention and Treatment of Chronic Hepatitis B(2019 Version)" .

Exclusion criteria

✕. Those concomitant HCV, HIV infection, alcoholic fatty liver disease, non-alcoholic fatty liver disease, and autoimmune liver disease , etc. were excluded.
✕. Diseases of the immune system or coagulation system, such as hyperthyroidism, diabetes, thrombocytopenic purpura, etc., were excluded.
✕. Exclude serious underlying diseases that affect the immune status of the body.
✕. The investigator believes that there are other circumstances that are not suitable for inclusion.

What they're measuring

The HBV-specific immune response levels will be measured using the immune cells from lymphoid follicle of the enrolled patients

Timeframe: After the tissue section collected

Trial details

NCT IDNCT07240350

SponsorNanfang Hospital, Southern Medical University

Sponsor typeOTHER

Study typeOBSERVATIONAL

Primary completion2026-12-31

Contact for this trial

Yongyin Li

+8613826039505 yongyinli@foxmail.com

View on ClinicalTrials.gov More Hepatitis B Virus Infection trials