The Mother-Daughter Project: Merck-4 (NCT07240220) | Clinical Trial Compass
Not Yet RecruitingNot Applicable
The Mother-Daughter Project: Merck-4
Kenya2,500 participantsStarted 2026-02-01
Plain-language summary
This project serves to continue a community-based initiative, known as the Kenya Mother-Daughter Cervical Cancer Eradication Project, or the Mother-Daughter Project (MDP), in the Webuye region of Western Kenya. The MDP project, since its initiation in 2018, has sought to develop a framework for the eradication of cervical cancer through effective screening of adult women and through the vaccination of female children.
This project specifically aims to collect additional data on the ability for HR-HPV testing to detect premalignant lesions of the cervix, especially in HIV-infected women, to investigate and identify barriers leading to non-participation in previous MDP efforts, and to examine factors associated with the immune response to HPV vaccination among rural Kenyan girls.
Who can participate
Age range
9 Years – 49 Years
Sex
FEMALE
See this in plain English?
AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
Kenyan Adult Women
Inclusion Criteria:
* ages 25 through 49 years
* able/willing to sign informed consent
* willing to participate in the community meetings
Exclusion Criteria:
• pregnant
Kenyan Girls
Inclusion Criteria:
* ages 9 through 14 years
* have mother that is able/willing to sign informed consent for vaccination
* can return for the second HPV vaccine dose in 6 - 12 months
Exclusion Criteria:
• girls who are not willing or unable to return for the second HPV vaccine dose
Questions worth asking your doctor
Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.
1Based on my diagnosis and history, is this trial worth exploring for me — or is there a standard treatment we should try first?
2What does this trial's phase tell us about how much is already known about its safety and benefit?
3What would taking part actually involve for me — visits, tests, time, and travel?
4What are the known and possible risks or side effects I should weigh, and how would they be monitored?
5If this trial isn't the right fit, what other options or trials would you suggest I look into?
Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.
Questions for the trial coordinator
The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.
1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?
A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.
What they're measuring
1
Detection of CIN2/3
Timeframe: Baseline
2
Local knowledge and attitudes
Timeframe: Baseline and after HPV vaccination of daughters is complete (assessed 2 weeks after second vaccine)
3
Barriers to participation
Timeframe: During a one-time interview
4
Factors that influence immunity to the HPV vaccine