ATC vs PSV for Weaning in Patients With Respiratory Failure (NCT07238140) | Clinical Trial Compass
CompletedNot Applicable
ATC vs PSV for Weaning in Patients With Respiratory Failure
Egypt50 participantsStarted 2019-05-26
Plain-language summary
Comparative study between automatic tube compensation and pressure support ventilation as a mode of weaning from mechanical ventilation in patients with respiratory failure
Who can participate
Age range
18 Years
Sex
ALL
See this in plain English?
AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
Inclusion Criteria:
* Age ≥18 years.
* Admitted with acute respiratory failure (ARF).
* On mechanical ventilation with Puritan-Bennett 840 ventilator for ≥24 hours.
* Considered for weaning after improvement or resolution of underlying cause.
* Fully conscious.
* Minimal or no requirement for vasoactive drugs or sedation.
* Adequate gas exchange (PaO₂/FiO₂ \>200 at PEEP 5 cmH₂O and FiO₂ \<0.5) Rapid shallow breathing index (RSBI) \<105 breaths/min/L.
Exclusion Criteria:
* Age \<18 years.
* Pre-existing chronic obstructive pulmonary disease (COPD).
* Neuromuscular disorders.
* Hemodynamic instability requiring high-dose vasoactive support.
* Persistent altered level of consciousness.
* Ongoing sedation.
* Severe metabolic or electrolyte disturbances.
* Morbid obesity (BMI ≥40 kg/m²).
* Tracheostomy.
* Pregnancy.
* Refusal to participate by patient or legal guardian.
Questions worth asking your doctor
Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.
1This trial compared two specific breathing support methods — Adaptive Support Ventilation and Pressure Support Ventilation — for weaning off the ventilator; can you explain which of these approaches you would use for me and why one might be better suited to my situation?
2Since this trial is already completed and was measuring how well patients' oxygen levels held up during a spontaneous breathing trial, has the data been published yet, and does it show any meaningful difference in oxygenation between the two methods that could influence my care?
3The trial focused on acute hypoxemic respiratory failure, which is my diagnosis — based on what's known from this study and others like it, how would you decide when I'm ready to attempt a spontaneous breathing trial, and what oxygen level would you be aiming for?
4Because this trial didn't have a traditional phase number, it seems to be more of a practical comparison of existing techniques rather than a test of something experimental — does that mean both ventilation methods are already considered standard care, and what are the real-world risks of each during the weaning process?
5If weaning from the ventilator turns out to be difficult for me, are there other completed or ongoing studies or protocols beyond what this trial tested that my care team would consider to support my recovery?
Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.
Questions for the trial coordinator
The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.
1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?
A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.
What they're measuring
1
Change in PaO₂/FiO₂ ratio (oxygenation index) during spontaneous breathing trial
Timeframe: Immediately before and at the end of the spontaneous breathing trial (SBT), assessed up to 2 hours