Effects of Personalized Digital Reminiscence Therapy on Patients With Neurocognitive Disorders (NCT07237009) | Clinical Trial Compass
RecruitingNot Applicable
Effects of Personalized Digital Reminiscence Therapy on Patients With Neurocognitive Disorders
France80 participantsStarted 2025-10-14
Plain-language summary
This study aims to observe the effects of daily personalized digital reminiscence sessions, conducted with the help of a digital conversational agent, and to determine whether these sessions lead to improvements in symptoms such as apathy and depression.
The researchers therefore seek to observe whether this daily use can improve certain aspects of well-being, such as motivation, mood, sleep quality, quality of life, and engagement with the tool.
The study also aims to assess whether simple reminders delivered via the application are sufficient to encourage regular use without external assistance.
Participants will:
* Use the reminiscence app for 25 days for 10-15 minutes.
* Have a primary caregiver help personalize the app by sharing family memories, other relatives may optionally contribute in a private group.
* Complete brief questionnaires at the start and during follow-up routine visits (for example, apathy and depression scales, sleep, and quality of life).
Who can participate
Age range
60 Years
Sex
ALL
See this in plain English?
AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
Inclusion Criteria:
* Men and women over 60 years of age.
* DSM-5 diagnosis: Early stage of major neurocognitive disorders or MCI (Mild Cognitive Impairment) including all underlying causes.
* Have a Mini-Mental State Exam score of 21 ≤ MMSE ≤ 28.
* Presence of mild or moderate depression, or presence of mild or moderate apathy, or presence of both
* Displays the necessary physical and cognitive abilities, without major limitations compromising interaction with the digital tool.
* Having voluntarily and informedly agreed to participate in the study (signed written consent).
* Subject's ability to hear and see the digital tool's stimuli (tests integrated into the tool).
* Patients with access to an Apple device (smartphone or tablet), either personal or provided by the sponsor, running iOS version 16 or higher, with internet access.
* Patient has at least one close referent who declares their wish to contribute to the collection of biographical information via the digital messaging group.
* Subjects covered by a social security scheme.
Exclusion Criteria:
* Patients with moderate or severe dementia (MMSE score ≤ 20) because implicit memory recall is less effective in moderate or severe stages for people with PWD.
* Presence of major psychiatric disorders (e.g., schizophrenia, severe major depressive episode, bipolar disorder).
* Major hearing or visual impairments.
* History of premorbid intellectual disability.
* Patients under guardianship, conservatorship, or legal prote…
Questions worth asking your doctor
Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.
1Based on my diagnosis and history, is this trial worth exploring for me — or is there a standard treatment we should try first?
2What does this trial's phase tell us about how much is already known about its safety and benefit?
3What would taking part actually involve for me — visits, tests, time, and travel?
4What are the known and possible risks or side effects I should weigh, and how would they be monitored?
5If this trial isn't the right fit, what other options or trials would you suggest I look into?
Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.
Questions for the trial coordinator
The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.
1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?
A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.
What they're measuring
1
Change in Montgomery-Åsberg Depression Rating Scale (MADRS) Total Score
Timeframe: Baseline, Day 25, Day 50.
2
Change in Lille Apathy Rating Scale (LARS) Total Score