Comparison of the Effectiveness of Dextrose Prolotherapy and Extracorporeal Shock Wave Therapy (E… (NCT07233395) | Clinical Trial Compass
Not Yet RecruitingNot Applicable
Comparison of the Effectiveness of Dextrose Prolotherapy and Extracorporeal Shock Wave Therapy (ESWT) in Plantar Fasciitis
60 participantsStarted 2025-11-15
Plain-language summary
Plantar fasciitis is a degeneration of the plantar aponeurosis and is the most common cause of heel pain (11-15%). Although seen in both sexes, plantar fasciitis is more common in women, usually unilateral and bilateral in 30% of cases . The most widely accepted view regarding the formation of plantar fasciitis is that it is a degenerative process caused by myxoid degeneration, microtears, collagen necrosis, and angiofibroblastic hyperplasia, resulting from repetitive microtrauma to the plantar fascia, particularly at the calcaneal insertion site. It is not inflammatory . The purpose of this study was to compare the effectiveness of prolotherapy, a regenerative treatment, and ESWT in the treatment of plantar fasciitis.
Who can participate
Age range
18 Years – 75 Years
Sex
ALL
See this in plain English?
AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
Inclusion Criteria:
* Diagnosis of plantar fasciitis
Ages 18 to 75 years
Both male and female participants
Heel pain localized to the medial calcaneal tubercle for more than 3 months
Morning first-step pain and pain increasing with daily loading
Willingness to participate and provide written informed consent
Patients presenting to Kanuni Sultan Süleyman Training and Research Hospital
Exclusion Criteria:
Cardiac pacemaker
Type 1 or Type 2 diabetes mellitus
History of inflammatory rheumatic disease
Bleeding disorders
Use of anticoagulant medications other than aspirin
Allergy to dextrose
Previous foot or ankle surgery
Peripheral neuropathy
S1 radiculopathy in the same extremity
Local corticosteroid injection to the plantar fascia within the last 3 months
ESWT applied to the plantar fascia within the last 3 months
Physical therapy applied to the foot/ankle in the last 3 months
Cognitive dysfunction
Active infection at the planned injection site
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Questions worth asking your doctor
Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.
1Based on my diagnosis and history, is this trial worth exploring for me — or is there a standard treatment we should try first?
2What does this trial's phase tell us about how much is already known about its safety and benefit?
3What would taking part actually involve for me — visits, tests, time, and travel?
4What are the known and possible risks or side effects I should weigh, and how would they be monitored?
5If this trial isn't the right fit, what other options or trials would you suggest I look into?
Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.
Questions for the trial coordinator
The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.
1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?
A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.
What they're measuring
1
Change in Heel Pain Intensity (VAS Score)
Timeframe: Baseline, 6 weeks, 12 weeks
Trial details
NCT IDNCT07233395
SponsorKanuni Sultan Suleyman Training and Research Hospital