Early Doppler-Assisted Mobilization in Adults After Acute Ischemic Stroke (NCT07232498) | Clinical Trial Compass
RecruitingNot Applicable
Early Doppler-Assisted Mobilization in Adults After Acute Ischemic Stroke
Portugal1,300 participantsStarted 2025-06-04
Plain-language summary
Post-stroke mobilization remains a subject of ongoing debate. While early mobilization-particularly the first out-of-bed mobilization-has been associated with reduced systemic complications and earlier rehabilitation, it also carries potential risks, such as neurological deterioration in the presence of hemodynamic instability.
In this study, the primary aim is to investigate whether early mobilization, guided by hemodynamic evaluation after acute ischemic stroke offers superior outcomes compared to standard clinical care.
Who can participate
Age range
18 Years
Sex
ALL
See this in plain English?
AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
Inclusion Criteria:
* Patients diagnosed with ischemic stroke aged 18 years or older;
* Ability to undergo carotid and transcranial Doppler ultrasound, as well as to mobilize within 48 hours;
* Informed consent obtained from the patient or legal representative.
Exclusion Criteria:
* Pre-existing disability with a modified Rankin Scale (mRS) score ≥ 4;
* Diagnosis of Transient Ischemic Attack (TIA);
* Severe hemodynamic instability, defined as:
* Systolic blood pressure \< 100 mmHg or \> 220 mmHg;
* Peripheral oxygen saturation \< 92%;
* Heart rate \< 40 or \> 112 beats per minute;
* Body temperature \> 38.5°C;
* Neurological deterioration with altered level of consciousness (defined as Glasgow Coma Scale \< 10);
* Patients who underwent neurosurgical intervention within the past 30 days;
* Concomitant diagnosis of a rapidly progressive fatal disease (e.g., terminal-stage cancer);
* Requirement for continuous monitoring or continuous intravenous drug infusion;
* Acute deep vein thrombosis/pulmonary embolism.
Questions worth asking your doctor
Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.
1Based on my diagnosis and history, is this trial worth exploring for me — or is there a standard treatment we should try first?
2What does this trial's phase tell us about how much is already known about its safety and benefit?
3What would taking part actually involve for me — visits, tests, time, and travel?
4What are the known and possible risks or side effects I should weigh, and how would they be monitored?
5If this trial isn't the right fit, what other options or trials would you suggest I look into?
Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.
Questions for the trial coordinator
The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.
1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?
A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.
What they're measuring
1
Functional status at 3 months after ischemic stroke