The study will evaluate the pharmacokinetic (PK) and pharmacodynamic (PD) responses of FMXIN002, an intranasal epinephrine powder, compared with the EpiPen® intramuscular autoinjector, after single and double doses, in healthy adults with a history of allergic rhinitis.
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Epinephrine level in plasma over time
Timeframe: -60 to 240 minutes post administration
Tmax
Timeframe: -60 to 240 minutes post administration
T100pg/ml
Timeframe: -60 to 240 minutes post administration
Cmax
Timeframe: -60 to 240 minutes post administration
AUC
Timeframe: 0 to 240 minutes post administration
Blood pressure
Timeframe: -60 to 120 minutes post administration
Heart rate
Timeframe: -60 to 120 minutes post administration
Respiratory rate
Timeframe: -60 to 120 minutes post administration