Not Yet RecruitingNot Applicable

IN PATIENTS WITH CORNEAL ABRASIONS TREATED WITH COLLAGEN CORNEAL SHIELDS IN THE EMERGENCY DEPARTMENT SETTING

60 participantsStarted 2026-05-15

Plain-language summary

This is a single-center, double-arm, patient masked, randomized controlled trial. Subjects will be enrolled in the Emergency Department at the Penn State Milton S. Hershey Medical Center. Eligible subjects must present to the ED and be diagnosed with a traumatic corneal abrasion. One eye from each patient will be considered the study eye.

Who can participate

Age range18 Years

SexALL

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Inclusion criteria

✓. Male or female, age 18 or older at the time of study enrollment.
✓. Corneal abrasion in one eye.
✓. Willingness to sign the IRB-approved informed consent form (ICF) for study participation.
✓. Availability, willingness, and sufficient cognitive awareness to return for study-required visits and comply with examination procedures.

Exclusion criteria

✕. Corneal abrasion in both eyes.
✕. Allergy to moxifloxacin or other fluoroquinolone antibiotics.
✕. Allergy to ibuprofen or other non-steroidal anti-inflammatory drugs.
✕. History of neurotrophic cornea for any reason, in the study eye.
✕. History of medical conditions known to cause decreased corneal sensation in the study eye including but not limited to HSV, HZO, and diabetes.
✕. History of extraocular surgical procedures known to cause decreased corneal sensation in the study eye, including but not limited to trigeminal nerve clamp.
✕. Any anterior segment pathology in the study eye that could significantly affect corneal wound healing (e.g. aniridia, clinically significant corneal dystrophies \[ABMD\], etc.)
✕. Any visually significant intraocular media opacity other than corneal abrasion in the study eye (as determined by the investigator). Such opacities might include corneal scar or vitreous hemorrhage.

What they're measuring

Pain Score 4 hours

Timeframe: four hours after leaving the emergency department.

Pain score 24 hours

Timeframe: 24 hours after discharge from the emergency department

Pain Score 72 hours

Timeframe: 72 hours after discharge from the emergency department

Trial details

NCT IDNCT07225699

SponsorMilton S. Hershey Medical Center

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2029-01-15

Contact for this trial

Uzma Muzammil, MBBS

717-531-0003 umuzammil@pennstatehealth.psu.edu

View on ClinicalTrials.gov More Corneal Abrasions trials