RecruitingNot Applicable

Hormonal Optimization: Late vs. Immediate Start After Discontinuation of Oral Contraceptives in Assisted Reproductive technologY (HOLIDAY)

United States394 participantsStarted 2026-02-25

Plain-language summary

HOLIDAY is a two-arm, parallel-group, multi-center, randomized trial in which subjects undergoing planned oocyte cryopreservation will be randomized to receive either a 2-month pause of Combined Hormonal Contraceptives (CHC) or immediate start (without a pause).

Who can participate

Age range18 Years – 40 Years

SexFEMALE

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Inclusion criteria

✓. Ovary-bearing individuals 18 to 40 years of age.
✓. BMI \< 40 kg/m2
✓. Non-smoker for at least 3 months prior to study enrollment.

Exclusion criteria

✕. BMI greater than or equal to 40 kg/m2
✕. Current Smoker
✕. Any contraindications to ovarian stimulation or outpatient egg retrieval under anesthesia

What they're measuring

Oocyte maturation rate

Timeframe: During oocyte retrieval

Number of oocytes retrieved

Timeframe: During oocyte retrieval

Trial details

NCT IDNCT07225660

SponsorShady Grove Fertility Reproductive Science Center

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2027-06-01

Contact for this trial

Tasha Newsome, Clinical Research Supervisor

301-545-1289 Tasha.Newsome@sgfertility.com

View on ClinicalTrials.gov More Fertility Preservation trials