Recovery of Physical Function After Critical Illness In Older Adults (NCT07225257) | Clinical Trial Compass
RecruitingNot Applicable
Recovery of Physical Function After Critical Illness In Older Adults
United States150 participantsStarted 2026-03-11
Plain-language summary
The proposed study is a prospective, observational study assessing the recovery of muscle and physical function in patients surviving critical illness (n =150) at hospital discharge (baseline) and repeated serially. Patients will be enrolled after life-saving modalities have been weaned near hospital discharge. Patients will participate in testing at baseline, 3-, 6-, 12-, and 24-months after hospital discharge. In a subset of patients (n = 18), muscle biopsies will be performed at baseline and then repeated once at either 12- or 24-months after hospital discharge.
Who can participate
Age range
18 Years – 99 Years
Sex
ALL
See this in plain English?
AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
Inclusion Criteria:
* adult patients (≥40 years of age)
* patients who have survived an ICU admission of at least 72 hours
* diagnosis of acute lung injury or sepsis are eligible.
Exclusion Criteria:
* individuals who were not ambulatory prior to ICU admission,
* not expected to survive at least 6 months,
* have a new or pre-existing brain infarct, injury, or neurological condition with deficits preventing participation in physical testing,
* have a pre-existing geriatric syndrome that were confound recovery trajectory
Questions worth asking your doctor
Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.
1This trial is focused on recovering physical function after a critical illness like sepsis or acute lung injury — given where I am in my recovery right now, does my doctor think my current level of function makes me a reasonable candidate to discuss this study with the research team?
2The trial measures muscle strength using something called a Chair Rise Test and tracks overall functional capacity — can my doctor explain what those measurements actually involve, and how demanding the physical assessments might be given my current condition?
3Since this trial is listed as 'Phase NA,' which often means it may be more of an observational or rehabilitation study rather than a drug trial, can my doctor help me understand what my actual participation would look like day-to-day and whether it would interfere with my standard recovery care?
4The trial focuses specifically on older adults recovering from sepsis or acute lung injury — can my doctor tell me whether the rehabilitation or interventions being studied in this trial are things I could access outside of the trial through standard care, or whether joining the study is the main way to access them?
5Given that this trial is actively recruiting, can my doctor help me understand the time commitment involved and whether participating would realistically fit into my current recovery schedule and any other treatments I'm already receiving?
Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.
Questions for the trial coordinator
The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.
1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?
A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.
What they're measuring
1
Muscle Strength measured by Chair Rise Test
Timeframe: Baseline and repeated 3-, 6-, 12-, and 24-months after baseline assessment.
2
Functional Capacity
Timeframe: Baseline and repeated 3-, 6-, 12-, and 24-months after baseline assessment.