The proposed study is a prospective, observational study assessing the recovery of muscle and physical function in patients surviving critical illness (n =150) at hospital discharge (baseline) and repeated serially. Patients will be enrolled after life-saving modalities have been weaned near hospital discharge. Patients will participate in testing at baseline, 3-, 6-, 12-, and 24-months after hospital discharge. In a subset of patients (n = 18), muscle biopsies will be performed at baseline and then repeated once at either 12- or 24-months after hospital discharge.
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Muscle Strength measured by Chair Rise Test
Timeframe: Baseline and repeated 3-, 6-, 12-, and 24-months after baseline assessment.
Functional Capacity
Timeframe: Baseline and repeated 3-, 6-, 12-, and 24-months after baseline assessment.