Aspirin in Reducing Events in the Elderly-Extension (ASPREE-XT)

Inclusion Criteria: * Men and women * African American and Hispanic persons age 65 or older * Any person from another ethnic minority group and Caucasian persons age 70 or older * Willing and able to provide informed consent, and willing to accept the study requirements Exclusion Criteria: * A history of a diagnosed cardiovascular event * A serious intercurrent illness likely to cause death within the next 5 years, such as terminal cancer or obstructive airways disease * A current or recurrent condition with a high risk of major bleeding, ex: cerebral aneurysm * Anemia * Absolute contraindication or allergy to aspirin * Current participation in a clinical trial * Current continuous use of aspirin or other anti-platelet drug or anticoagulant for secondary prevention. People with previous use of aspirin for primary prevention may enter the trial, provided they agree to cease existing use of aspirin and understand that they may be subsequently randomly allocated to low dose aspirin or placebo. * A systolic blood pressure ≥180 mmHg and / or a diastolic blood pressure ≥105 mmHg * A history of dementia * Severe difficulty or an inability to perform any one of the 6 Katz ADLs * Non-compliance to taking pill