The Effects of Ketone Supplements With Carbohydrates on Cycling Performance Above Lactate Threshold (NCT07224282) | Clinical Trial Compass
Not Yet RecruitingEarly Phase 1
The Effects of Ketone Supplements With Carbohydrates on Cycling Performance Above Lactate Threshold
United States15 participantsStarted 2025-11-17
Plain-language summary
The goal of this clinical trial is to determine whether a ketone supplement with carbohydrates extends time to fatigue during cycling compared with a carbohydrate-only supplement in healthy, trained cyclists aged 18-55. The main questions it aims to answer are:
Is the time to fatigue increased with ketone supplementation and carbohydrates compared to carbohydrates alone? Will ketone supplementation with carbohydrates produce lower blood lactate concentrations compared to carbohydrates alone?
Participants will:
* Perform a staged maximal cycling exercise test on a stationary bicycle.
* Finger prick to obtain a drop of blood for lactate measurements.
* Wear a mask connected to a metabolic cart to measure breath contents.
* Perform a cycling exercise test to fatigue for at least one hour.
* Consume either a ketone supplement with carbohydrates or a carbohydrate supplement during the exercise at least 4 times.
* Finger prick to obtain a drop of blood to measure blood lactate, ketones, and glucose.
Who can participate
Age range
18 Years – 55 Years
Sex
ALL
See this in plain English?
AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
Inclusion Criteria:
* Highly trained males and females
* Ages 18-55
* Greater than or equal to six hours of cycling training per week
* Participants from the University of Oklahoma, Oklahoma cycling teams, and local cycling races in Oklahoma.
Exclusion Criteria:
* Cardiovascular disease
* Respiratory disease
* Gastrointestinal disease
* Metabolic disease
* Kidney disease
* Neurological disease
* Pregnancy
Questions worth asking your doctor
Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.
1Based on my diagnosis and history, is this trial worth exploring for me — or is there a standard treatment we should try first?
2What does this trial's phase tell us about how much is already known about its safety and benefit?
3What would taking part actually involve for me — visits, tests, time, and travel?
4What are the known and possible risks or side effects I should weigh, and how would they be monitored?
5If this trial isn't the right fit, what other options or trials would you suggest I look into?
Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.
Questions for the trial coordinator
The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.
1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?
A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.
What they're measuring
1
Time to fatigue
Timeframe: Through study completion, an average of 2 weeks.