Effects of P-TIOX and Tixel Combined on Reducing Eye Wrinkles (NCT07222176) | Clinical Trial Compass
Active — Not RecruitingNot Applicable
Effects of P-TIOX and Tixel Combined on Reducing Eye Wrinkles
United States20 participantsStarted 2025-06-01
Plain-language summary
This study looks at whether using a cosmeceutical called P-TIOX together with a treatment called Tixel can reduce fine lines and wrinkles around the eyes better than Tixel treatment alone. Tixel is an FDA-approved device that uses heat to improve skin texture and firmness. P-TIOX is a topical product with ingredients that may help improve the skin's appearance and elasticity.
One side of the face will be treated with both P-TIOX and Tixel, while the other side will receive Tixel only. The study will last about 9 weeks and will include several treatments and evaluations using photos and expert assessments.
Participants may notice improvement in the skin around their eyes. The results will help doctors understand if this combination treatment is more effective.
Who can participate
Age range
30 Years
Sex
ALL
See this in plain English?
AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
Inclusion Criteria:
* Severity of 2, 3, or 4 based on the 5-point severity scale of both periocular areas
* 30 years of age or older
* Willingness to comply with study visits
* Willingness to discontinue use of other topical cosmeceuticals/retinoids to the periocular region for the duration of the study
Exclusion Criteria:
* Pregnant or breastfeeding
* Prior treatment with periocular laser, energy-based devices, neuromodulators, or dermal fillers within the past six months
* Prior surgical intervention in the periocular region within the past twelve months
* Use of topical retinoids in the periocular area within the past four weeks
* Known hypersensitivity to any component of P-TIOX
* Presence of active dermatologic or ocular disease in the treatment area
* Active systemic infection
* Active cold sore/herpes labialis infection
Questions worth asking your doctor
Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.
1Based on my diagnosis and history, is this trial worth exploring for me — or is there a standard treatment we should try first?
2What does this trial's phase tell us about how much is already known about its safety and benefit?
3What would taking part actually involve for me — visits, tests, time, and travel?
4What are the known and possible risks or side effects I should weigh, and how would they be monitored?
5If this trial isn't the right fit, what other options or trials would you suggest I look into?
Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.
Questions for the trial coordinator
The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.
1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?
A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.
What they're measuring
1
Objective change in Periocular Fine Lines and Wrinkles by Canfield Visia Imaging Analysis
Timeframe: From baseline (Week 0) to final follow-up visit (Week 8 ± 7 days after initial Tixel treatment).