RecruitingNot Applicable

Integrating Project YES! With WHO-Endorsed Mental Health Approaches Among Youth Living With HIV

Zambia400 participantsStarted 2025-10-25

Plain-language summary

The proposed study will address the intersecting stigmas of HIV, violence and depression among adolescents and young adults (15-24) living with HIV (AYALHIV) in Zambia. The study will integrate a WHO-endorsed mental health approach into an existing HIV-stigma-reducing intervention, and refine measures of internalized and intersecting stigmas, to create and test the feasibility of Project YES+- a combined youth peer mentoring and lay mental health intervention. This research aims to shift HIV care and treatment for AYALHIV by addressing the multiple internalized and intersecting stigmas that impeded antiretroviral adherence and HIV viral suppression.

Who can participate

Age range15 Years

SexALL

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AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria: For youth * Be between ages 15-21 * living within 30-minutes, by personal transportation, of the clinic by self-report, * and being available to attend sessions and data collection over a 4-8 month time period On ART for at least 6 months * On first-line ART * Speaks Bemba For caregivers * Being 25 years of age or older * Caring for an AYALHIV who meets the study eligibility criteria * Speaks Bemba * Living within 30-minutes, by personal transportation, of the clinic by self-report * Being available to attend sessions and data collection over a 4-8 month time period Exclusion Criteria: For youth, * only one youth per household may join. * Also participants will be excluded from joining the RCT if they are at imminent risk of suicide based on WHO guidance on the Self Help plus program.

What they're measuring

Feasibility of intervention as assessed by percentage of sessions attended

Timeframe: Up to 4 months

Number of intervention participants who report they would recommend Project YES+ to their peers

Timeframe: up to 4 months

Number of intervention participants who would recommend Project YES+ for caregivers

Timeframe: up to four months

Trial details

NCT IDNCT07221201

SponsorJohns Hopkins Bloomberg School of Public Health

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2026-06-15

Contact for this trial

Julie A Denison, PhD

13012838643 jdenison@jhu.edu

View on ClinicalTrials.gov More HIV - Human Immunodeficiency Virus trials