By InvitationPhase 4

Comparison of Suzetrigine and Oxycodone for Postoperative Pain After Primary Total Knee Arthroplasty

United States140 participantsStarted 2026-02-09

Plain-language summary

The purpose this study is determine whether postoperative oral dosage of suzetrigine is effective at controlling postoperative pain and reducing analgesic requirements following primary total knee arthroplasty (TKA) versus a control group of TKA patients receiving postoperative Oxycodone.

Who can participate

Age range21 Years – 89 Years

SexALL

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AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion criteria

✓. Patient age is 21-89 at time of surgery
✓. Patient is scheduled to undergo a unilateral primary TKA, secondary to osteoarthritis
✓. Patient agrees to participate as a study subject and signs the Informed Consent and Research Authorization document
✓. Patient is able to read and speak English.

Exclusion criteria

✕. Patient is under the age of 21
✕. Patient's primary diagnosis is not osteoarthritis
✕. Patient is unable to read and speak English
✕. Contraindication or Hypersensitivity to suzetrigine
✕. Pregnant or nursing females
✕. Patient has taken opioids within the 90 days prior to enrollment

What they're measuring

Daily Opioid Use POD 1-14

Timeframe: 2 weeks

total opioid usage over two weeks

Timeframe: 2 weeks

Use of supplemental opioid POD 1-14

Timeframe: 2 weeks

VAS pain score over two weeks

Timeframe: 2 weeks

Opioid Usage at 6 weeks postop

Timeframe: 6 weeks

Trial details

NCT IDNCT07219888

SponsorUniversity of Louisville

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2026-12-31

View on ClinicalTrials.gov More Osteoarthritis (OA) of the Knee trials