The purpose of this study is to learn what happens to calderasib levels in a person's body over time. Researchers will measure what happens to calderasib levels in the body when it is given to participants with hepatic (liver) impairment and healthy participants. Researchers also want to learn about the safety of MK-1084 when it is given to people with hepatic impairment and if people with hepatic impairment can tolerate it.
Age range
18 Years – 80 Years
Sex
ALL
See this in plain English?
AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.
Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.
The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.
A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.
Area Under the Concentration Versus Time Curve from 0 to the Time of the Last Quantifiable Sample (AUC0-last) of Calderasib
Timeframe: At designated timepoints up to approximately 7 days post-dose
Area Under the Concentration Versus Time Curve from 0 to Infinity (AUC0-inf) of Calderasib
Timeframe: At designated timepoints up to approximately 7 days post-dose
Area Under the Concentration Versus Time Curve from 0 to 24 hours post-dose (AUC0-24) of Calderasib
Timeframe: Up to approximately 24 hours post-dose
Maximum Observed Drug Concentration (Cmax) of Calderasib
Timeframe: At designated timepoints up to approximately 7 days post-dose
Time to Maximum Observed Drug Concentration (Tmax) of Calderasib
Timeframe: At designated timepoints up to approximately 7 days post-dose
Apparent Terminal Half-life (t1/2) of Calderasib
Timeframe: At designated timepoints up to approximately 7 days post-dose
Apparent Clearance (CL/F) of Calderasib
Timeframe: At designated timepoints up to approximately 7 days post-dose
Apparent Volume of Distribution During Terminal Phase (Vz/F) of Calderasib
Timeframe: At designated timepoints up to approximately 7 days post-dose