Residual IDH1-Mutant Tumor Cell Quantification Study

Inclusion Criteria: * Age ≥ 18 years at the time of consent (any sex) * Newly diagnosed diffuse glioma with either (a) radiographic features consistent with IDH-mutant glioma or (b) prior molecular confirmation of an IDH mutation * Scheduled for tumor tissue biopsy or surgical resection at NYU Langone Health Exclusion Criteria: • Active hepatitis C virus (HCV) infection or suspected/confirmed prion disease (e.g., Creutzfeldt-Jakob disease), as documented in the medical record or by the treating physician, due to biosafety and tissue- handling restrictions