Not Yet RecruitingNot Applicable

Behavioral Safety and Fentanyl Education: BSAFE

United States160 participantsStarted 2026-06-15

Plain-language summary

BSAFE is a randomized trial of a repeated-dose brief intervention to reduce overdose and risk behaviors among people who use stimulants who may have unintentional fentanyl use (UFU). It includes an established overdose education curriculum within an Informational-Motivation-Behavior (IMB) model. This study will test the efficacy of BSAFE vs attention-control.

Who can participate

Age range18 Years

SexALL

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Inclusion criteria

✓. Aged 18 years or older,
✓. Reports intentional cocaine or methamphetamine use \>15 of past 30 days,
✓. Urine positive for cocaine or methamphetamine and negative for opioids/fentanyl prior to enrollment
✓. Be able to provide the names of at least 2 persons who can consistently locate their whereabouts.

Exclusion criteria

✕. Reports past 30-day intentional use of any opioid or ongoing use of an opioid antagonist (e.g., naltrexone)
✕. Intends to leave area in coming year,
✕. Unable to communicate in English or Spanish,
✕. Any other condition that, in the PI's judgment, interferes with safe study participation or adherence to study procedures.

What they're measuring

Incidence of opioid overdose due to unintentional fentanyl use

Timeframe: 16 months

Trial details

NCT IDNCT07219082

SponsorSan Francisco Department of Public Health

Sponsor typeOTHER_GOV

Study typeINTERVENTIONAL

Primary completion2030-01-15

Contact for this trial

Phillip O Coffin, MD, MIA

(628) 217-6282 phillip.coffin@sfdph.org

View on ClinicalTrials.gov More Drug Overdose trials