Evaluation of the Safety and Effects of Psychoactive Substances in People With Past Opioid Use

Inclusion criteria

• ✓. English-speaking, 18- to 55-year-old males or females.
• ✓. Female subjects must have a negative serum pregnancy test at time of screening and negative urine pregnancy test upon admission. In addition, female subjects must meet one of the following conditions:
• ✓. Male subjects must agree to the following from Day 1 until 9 months after receiving the study medication:
• ✓. Physically healthy, as determined by a clinical interview with a physician, laboratory tests (urinalysis, blood chemistry, 12-lead ECG), physical examination, and self-reported medical history.
• ✓. No current or past diagnosis of severe mental illness, as determined by a clinical interview.
• ✓. Clinical laboratory test results (CMP, CBC, etc.) must be within the normal reference range or with acceptable deviations that are judged to be not clinically significant by a study physician.
• ✓. Have a history of self-reported recreational opioid use as defined by at least 10 times in the past year and at least once in the 12 weeks before screening.
• ✓. Able and willing to give signed informed consent, reliable, and willing to make themselves available for the study's duration and follow study procedures.

Exclusion criteria