RecruitingNot Applicable

Trans-Auricular Stimulation for Postoperative Inflammation in Spine Surgery

United States50 participantsStarted 2025-10-08

Plain-language summary

This study is a randomized controlled trial that will evaluate the effect of non-invasive auricular vagal nerve stimulation on inflammatory markers, glycemic control, postoperative pain, and inflammation-related clinical outcomes after long-segment spinal fusion surgeries when compared to current accepted management.

Who can participate

Age range18 Years

SexALL

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria: * Long-segment spinal fusions (defined as constructs spanning at least L2-pelvis for thoracolumbar fusions or C2-T2 for cervical fusions) * Ability to undergo a reliable neurologic examination and pain assessments Exclusion Criteria: * Patients \<18 years of age * Shorter-segment spinal fusions than those described above * Undergoing current active cancer therapy * Undergoing treatment with immunosuppressive drugs * Additional spinal surgery within past 6 months * Sustained bradycardia or presence of pacemaker * History of substance abuse

What they're measuring

Inflammatory cytokine levels

Timeframe: 5-10 days (depending on hospital admission length)

Trial details

NCT IDNCT07218133

SponsorAlexander T. Yahanda

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2026-05

Contact for this trial

Alexander T Yahanda, MD, MPHS

3143690198 ayahanda@wustl.edu

View on ClinicalTrials.gov More Spinal Fusion trials